C8417
N-(2-氯乙基)-N-乙基-2-溴苄胺 盐酸盐
≥98% (TLC), solid, adrenergic neurotoxin
别名:
DSP-4, N-乙基-N-(2-氯乙基)-2-溴苄胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C11H15BrClN · HCl
化学文摘社编号:
分子量:
313.06
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
Beilstein/REAXYS Number:
4020910
产品名称
N-(2-氯乙基)-N-乙基-2-溴苄胺 盐酸盐, ≥98%, solid
InChI
1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H
SMILES string
Cl[H].CCN(CCCl)Cc1ccccc1Br
InChI key
NDDRNRRNYOULND-UHFFFAOYSA-N
assay
≥98%
form
solid
color
white
solubility
H2O: 48 mg/mL, 0.1 M NaOH: 7 mg/mL, ethanol: soluble
Quality Level
相关类别
Biochem/physiol Actions
肾上腺素能神经毒素诱导中枢和外周去甲肾上腺素能神经末梢的急性和相对选择性变性。
Preparation Note
乙醇、水或0.1N NaOH溶液应在临用前配制。
Disclaimer
吸湿的。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
T Kushikata et al.
British journal of anaesthesia, 107(6), 924-929 (2011-10-04)
Central noradrenergic neurones have a role in alertness, analgesia, and thermoregulation; these neurones are also involved in the mechanism of anaesthesia. Locus coeruleus neurones innervate various central nervous regions including the cerebral cortex and hippocampus, and are responsible for wakefulness
Maria Vittoria Simonini et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 5(2), 252-259 (2009-12-04)
The endogenous neurotransmitter noradrenaline (NA) is known to exert potent anti-inflammatory effects in glial cells, as well as provide neuroprotection against excitatory and inflammatory stimuli. These properties raise the possibility that increasing levels of NA in the central nervous system
Anna Sadakierska-Chudy et al.
Biochemical pharmacology, 86(6), 800-807 (2013-08-09)
The aim of the present study was to examine the effect of the brain noradrenergic system on the expression of cytochrome P450 in the liver. The experiment was carried out on male Wistar rats. Intracerebroventricular injection of the noradrenergic neurotoxin
Clement Hamani et al.
Biological psychiatry, 67(2), 117-124 (2009-10-13)
Subcallosal cingulate gyrus (SCG) deep brain stimulation (DBS) is being investigated as a treatment for major depression. We report on the effects of ventromedial prefrontal cortex (vmPFC) DBS in rats, focusing on possible mechanisms involved in an antidepressant-like response in
Ee Peng Lim et al.
The international journal of neuropsychopharmacology, 13(9), 1219-1231 (2010-02-05)
Stimulation of the subiculum/CA1 of the hippocampal formation evokes monosynaptic field potentials in the prefrontal cortex (PFC). High-frequency stimulation of the hippocampus (HPC) can induce long-term potentiation (LTP) in this hippocampo-prefrontal cortical (hippo-PFC) pathway. Previous studies have shown that dopamine
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