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C8195

Sigma-Aldrich

Complement C4 来源于人类血清

≥300,000 C4H50 units/mg protein

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About This Item

CAS号:
80295-48-3
MDL编号:
MFCD00130838
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

human serum

质量水平

200

表单

solution

比活

≥300,000 C4H50 units/mg protein

技术

activity assay: suitable

UniProt登记号

P0C0L4

运输

dry ice

储存温度

−70°C

基因信息

human ... C4A(720)

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一般描述

Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein.

应用

Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples.

生化/生理作用

Complement C4 serves a primary role in the classical and lectin pathways of the complement system and provides protection against bacterial pathogens. C4 polymorphisms have been used in research to study their associations with the hemolytic and antibacterial ability of the classical pathway.
There are strong indications that complement C4 deficiency is correlated with induction of systemic lupus erythematosus (SLE) and other autoimmune diseases.
Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia.

外形

Supplied as a solution in PBS, pH 7.2

其他说明

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

免责声明

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCM7811
SLCH8255
SLCF0437
SLBW9849
SLBN3829V

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What is the molecular weight of Product C8195, Complement C4 from human serum?

    The molecular weight for Product C8195, Complement C4 from human serum, is 205,000 daltons as described in Complement: A Practical Approach, A.W. Dodds and R.B. Sim, Eds., p. 2, 1997.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Yan Yang et al.
Current directions in autoimmunity, 7, 98-132 (2004-01-15)
It was observed about 50 years ago that low serum complement activity or low protein concentrations of complement C4 concurred with disease activities of systemic lupus erythematosus (SLE). Complete deficiencies of complement components C4A and C4B, albeit rare in human
Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4
Blanchong CA, et al.
International Immunopharmacology, 1(3), 365-392 (2001)
Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney
Bay JT, et al.
Kidney International, 84(3), 562-569 (2013)
Structural basis for the function of complement component C4 within the classical and lectin pathways of complement
Mortensen S, et al
Journal of Immunology (2015)
Structural basis for activation of the complement system by component C4 cleavage
Kidmose RT, et al.
Proceedings of the National Academy of Sciences of the USA, 109, 15425-15430 (2012)
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