一般描述
Cholera Toxin (CT) is secreted by Vibrio cholerae. CT upregulates cell surface molecules, such as co-stimulatory molecules and chemokine receptors in antigen presenting cells(APCs), murine and human dendritic cells (DCs). It enhances the secretion of interleukin 1 (IL-1) from macrophages and stimulates their APC function. CT also functions as an immunomodulator.
应用
Cholera Toxin A Subunit from Vibrio cholerae has been used as a specific probe for trimeric G proteins in membrane motility assays.
生化/生理作用
Catalyzes ADP-ribosylation of the α-subunit of G proteins, reducing GTPase activity and activating the α-subunit; also catalyzes ADP-ribosylation of cell membrane adenylyl cyclase
外形
Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA
重悬
When reconstituted with 1 mL of water, the solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN3, and 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Inhalation - Aquatic Chronic 3
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Actions of cholera toxin and the prevention and treatment of cholera
Holmgren J.
Nature, 292(5822), 413-413 (1981)
In Vitro Reconstitution of Microtubule Plus End-directed, GTPgammaS-sensitive Motility of Golgi Membranes
Fullerton AT, et al.
Molecular Biology of the Cell, 9(10), 2699-2714 (1998)
Cholera toxin: a paradigm of a multifunctional protein
Bharati K and Ganguly NK
The Indian Journal of Medical Research, 133(2), 179-179 (2011)
Irina N Marinova et al.
STAR protocols, 2(3), 100668-100668 (2021-09-07)
Glycosylation is one of the most common protein modifications in living organisms and has important regulatory roles in animal tissue development and homeostasis. Here, we present a protocol for generation of 3D organotypic skin models using CRISPR-Cas9 genetically engineered human
Yingqi Liu et al.
eLife, 9 (2020-08-28)
Arginine methyltransferase PRMT7 is associated with human breast cancer metastasis. Endosomal FAK signalling is critical for cancer cell migration. Here we identified the pivotal roles of PRMT7 in promoting endosomal FAK signalling activation during breast cancer metastasis. PRMT7 exerted its
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