C8145
Cefsulodin sodium salt hydrate
third-generation cephalosporin antibiotic
别名:
7-(D-α-Sulfophenylacetamido)ceph-3-em-3-(4′-carbamoylpyridinium)methyl-4-carboxylate sodium salt
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所有图片(1)
About This Item
经验公式（希尔记法）:
C22H19N4NaO8S2 · xH2O
CAS号:
分子量:
554.53 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
51284140
PubChem化学物质编号:
NACRES:
NA.85
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质量水平
表单
powder or crystals
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
cell wall synthesis | interferes
储存温度
2-8°C
SMILES字符串
[Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S([O-])(=O)=O)C3=O)C([O-])=O)cc1
InChI
1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1
InChI key
REACMANCWHKJSM-DWBVFMGKSA-M
一般描述
Chemical structure: ß-lactam
应用
Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. Cefuslodin is used in CIN (cefsulodin-Irgasan-novobiocin) agar to select for microorganisms such as E. coli. Cefsulodin is a substrate for rat Oatp1a4. It has been used to study multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across the mouse blood-brain barrier.
Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
生化/生理作用
Cefsulodin is a cephalosporin. Cephalosporins disrupt cell wall synthesis by inhibiting PBP crosslinking of peptidoglycan.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Friederike Hilbert et al.
International journal of food microbiology, 84(1), 111-115 (2003-06-05)
Yersinia enterocolitica is an important foodborne pathogen, but isolation of virulent Yersinia from food sources is still time consuming and requires skills. In this article, we describe a rapid urease screening on cefsulodin-irgasan-novobiocin (CIN) agar plates with an agar overlay
Miguel Angel de Pedro et al.
Microbiology (Reading, England), 148(Pt 1), 79-86 (2002-01-10)
Periodic activation of zonal peptidoglycan (murein) synthesis at division sites in Escherichia coli has been reported recently. Zonal synthesis is responsible for septum formation, whereas elongation of the cell sacculus is performed by diffuse insertion of precursors. Zonal synthesis can
Paul G Higgins et al.
Water research, 140, 261-267 (2018-05-04)
The elimination of potentially pathogenic bacteria in wastewater treatment plants (WWTPs) attracts much attention in public health. Reports on the occurrence of the emerging hospital pathogen Acinetobacter baumannii in wastewaters do not include a continuous monitoring at all WWTP stages.
T H Tsai et al.
Journal of chromatography. A, 914(1-2), 83-87 (2001-05-19)
A microdialysis method followed by a microbore liquid chromatographic ultraviolet detection procedure has been performed for the assay of unbound cefsulodin in rat blood. A microdialysis probe was inserted into the jugular vein for blood sampling. This method involves an
C L Baylis
Journal of applied microbiology, 105(5), 1259-1265 (2008-08-21)
This study compared the growth of different strains of Verocytotoxin-producing Escherichia coli (VTEC) in a range of selective enrichment media. Turbidometric and impedance methods were used to determine the growth of VTEC in pure culture in different enrichment media. Ten
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