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C8124

CH-223191

Name: CH-223191
Brand: SIGMA

≥98% (HPLC), powder, AhR antagonist

别名:

1-甲基-氮-[2-甲基-4-[2-（2-甲基苯基）二氮烯基]苯基-1H-吡唑-5-甲酰胺, 2-甲基-2H-吡唑-3-羧酸（2-甲基-4-邻甲苯偶氮-苯基）-酰胺

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About This Item

经验公式（希尔记法）:

C₁₉H₁₉N₅O

CAS号:

301326-22-7

分子量:

333.39

MDL编号:

MFCD00377884

UNSPSC代码:

12352200

PubChem化学物质编号:

329775161

NACRES:

NA.77

product name

CH-223191,

检测方案

≥98% (HPLC)

质量水平

100

形式

powder

颜色

orange-brown

溶解性

DMSO: ≥20 mg/mL

储存温度

2-8°C

SMILES字符串

Cc1cc(ccc1NC(=O)c2ccnn2C)\N=N\c3ccccc3C

InChI

1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)/b23-22+

InChI key

LKTNEXPODAWWFM-GHVJWSGMSA-N

应用

CH-223191已被用作肝素细胞、TH17-白细胞介素-10+细胞和有机类中的芳香烃受体（AHR）拮抗剂。

生化/生理作用

CH-223191是一种强效特异性芳香烃受体（AhR）拮抗剂。它抑制TCDD介导的核转位和AhR的脱氧核糖核酸结合，并抑制TCDD诱导的荧光素酶活性，IC50为30纳米。与其他在高浓度下显示激动剂活性的AhR拮抗剂不同，CH-223191即使在100微摩尔时也不能刺激AhR依赖性转录。它也对AhR有特异性，对雌激素受体没有亲和力，就像其他拮抗剂一样。

特点和优势

该化合物在受体分类和信号转导手册中核受体（非甾体化合物）页面中进行了详细介绍。欲浏览其他手册页面，请点击这里。

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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The Aryl Hydrocarbon Receptor Attenuates Acute Cigarette Smoke-Induced Airway Neutrophilia Independent of the Dioxin Response Element.

Angela Rico de Souza et al.

Frontiers in immunology, 12, 630427-630427 (2021-03-05)

Cigarette smoke is a prevalent respiratory toxicant that remains a leading cause of death worldwide. Cigarette smoke induces inflammation in the lungs and airways that contributes to the development of diseases such as lung cancer and chronic obstructive pulmonary disease

Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of alpha-endosulfan and dioxin in HepaRG human cells

Attignon E, et al.

Toxicology in vitro, 45, 309-317 (2017)

Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis.

Qin Wang et al.

Environmental health perspectives, 121(11-12), 1334-1343 (2013-09-24)

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of xenobiotic detoxification genes and is a critical mediator of gene-environment interactions. Many AHR target genes identified by genome-wide gene expression profiling have morphogenetic functions, suggesting

An immunoregulatory and tissue-residency program modulated by c-MAF in human TH 17 cells

Aschenbrenner D, et al.

Nature Immunology, 19(10), 1126-1126 (2018)

Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization.

Lei Dong et al.

Scientific reports, 6, 36598-36598 (2016-11-04)

Understanding of T helper 17 lineage (T

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