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Merck
CN

C8124

CH-223191

≥98% (HPLC), powder, AhR antagonist

别名:

1-甲基-氮-[2-甲基-4-[2-（2-甲基苯基）二氮烯基]苯基-1H-吡唑-5-甲酰胺, 2-甲基-2H-吡唑-3-羧酸（2-甲基-4-邻甲苯偶氮-苯基）-酰胺

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关于此项目

经验公式（希尔记法）:
C19H19N5O
化学文摘社编号:
301326-22-7
分子量:
333.39
UNSPSC Code:
12352200
PubChem Substance ID:
329775161
NACRES:
NA.77
MDL number:
MFCD00377884

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产品名称

CH-223191,

SMILES string

Cc1cc(ccc1NC(=O)c2ccnn2C)\N=N\c3ccccc3C

InChI key

LKTNEXPODAWWFM-GHVJWSGMSA-N

InChI

1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)/b23-22+

assay

≥98% (HPLC)

form

powder

color

orange-brown

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

Quality Level

100

相关类别

Application

CH-223191已被用作肝素细胞、TH17-白细胞介素-10+细胞和有机类中的芳香烃受体（AHR）拮抗剂。

Biochem/physiol Actions

CH-223191是一种强效特异性芳香烃受体（AhR）拮抗剂。
CH-223191是一种强效特异性芳香烃受体（AhR）拮抗剂。它抑制TCDD介导的核转位和AhR的脱氧核糖核酸结合，并抑制TCDD诱导的荧光素酶活性，IC50为30纳米。与其他在高浓度下显示激动剂活性的AhR拮抗剂不同，CH-223191即使在100微摩尔时也不能刺激AhR依赖性转录。它也对AhR有特异性，对雌激素受体没有亲和力，就像其他拮抗剂一样。

Features and Benefits

该化合物在受体分类和信号转导手册中 核受体（非甾体化合物） 页面中进行了详细介绍。欲浏览其他手册页面，请 点击这里。
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000459475
0000459475
0000388488
0000388490
0000157504

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