所有图片(1)
About This Item
经验公式（希尔记法）:
C29H37N3O6
CAS号:
分子量:
523.62
Beilstein:
1096801
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
无菌性
non-sterile
质量水平
方案
≥98% (TLC)
表单
powder
颜色
white to light yellow
溶解性
ethanol: 5 mg/mL
DMSO: 50 mg/mL
抗生素抗菌谱
Gram-positive bacteria
fungi
作用机制
cell membrane | interferes
储存温度
2-8°C
SMILES字符串
[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
InChI
1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
InChI key
HIYAVKIYRIFSCZ-CYEMHPAKSA-N
正在寻找类似产品? 访问 产品对比指南
一般描述
钙离子载体A23187是一种羧酸类抗生素，在体外抗革兰氏阳性菌的活性较弱。它可增加二价离子穿过生物膜的电位，因此起到离子载体的作用。钙离子载体A23187特异性地与二价阳离子形成稳定的2:1复合物，使这些离子可溶于普通有机溶剂。由于钙离子载体A23187通常用于增加完整细胞内的Ca2+水平，它可用作氧化磷酸化的解偶联剂和线粒体腺苷三磷酸酶（ATPase）活性的抑制剂。钙离子载体A23187是弓形虫真核起始因子-2α（eIF2α）磷酸化作用的有效诱导物。此外，它不仅在小鼠淋巴瘤系（S49）7中诱导凋亡；还显示出可以阻断其他系统中的凋亡，例如当白介素3（IL-3）从IL-3依赖性细胞中除去时。钙离子载体A23187广泛用作人卵母细胞的人工辅助激活物。
with heating or sonication. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.
with heating. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.
应用
钙离子载体A23187已：
- 用作内质网（ER）应激诱导剂，以研究其对弓形虫未折叠蛋白反应（UPR）基因表达的影响
- 用于诱导顶体反应
- 用于骨骼肌肌浆网Ca2+ATPase (SERCA)的活性测定
离子载体对Ca2+具有高度选择性。 增强对NMDA的反应，而不是使君子氨酸。 在细胞培养中，通过钙调素依赖的构成型一氧化氮合酶刺激一氧化氮的产生。
通常也和此产品一起购买
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Jeannine Winkler et al.
Thrombosis and haemostasis, 109(3), 532-539 (2013-01-12)
Although platelets possess the hallmarks of apoptosis such as activation of caspases, cytochrome c release and depolarisation of the mitochondrial transmembrane potential (∆Ψm), their entire apoptotic-signalling pathway is not totally understood. Therefore we studied the expression of various apoptotic proteins
Jun Suzuki et al.
The Journal of biological chemistry, 288(19), 13305-13316 (2013-03-28)
TMEM16A and 16B work as Cl(-) channel, whereas 16F works as phospholipid scramblase. The function of other TMEM16 members is unknown. Using TMEM16F(-/-) cells, TMEM16C, 16D, 16F, 16G, and 16J were shown to be lipid scramblases. Some TMEM16 members are
Asuman Mutlu et al.
British journal of haematology, 163(3), 377-384 (2013-09-17)
The cell plasma membrane is tightly coupled with the vital processes of apoptosis and activation. In the current study, we investigated exposure of the apoptosis marker phosphatidylserine (PS) and activation marker P-selectin (CD62) on the plasma membrane of anucleate platelets.
Sharissa L Latham et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(2), 672-683 (2012-11-20)
Elevated endothelial microparticle (MP) levels are observed in numerous diseases, increasingly supporting roles as effectors and valuable markers of vascular dysfunction. While a contractile role for the actin cytoskeleton has been implicated in vesiculation, i.e., MP production, the precise interactions
Armen V Gyulkhandanyan et al.
British journal of haematology, 161(2), 245-254 (2013-02-13)
Anucleate platelets perform two fundamental processes, activation and apoptosis. We elaborated an approach for selective and concurrent stimulation of platelet apoptosis and/or activation, processes important in haemostasis and platelet clearance. Human platelets were treated with BH3 mimetic ABT-737, thrombin, calcium
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门