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Merck
CN

C7397

环磷酰胺 一水合物

ISOPAC®

别名:

2-[双(2-氯乙基)氨基]四氢-2H-1,3,2-噁磷-2-氧化物, Cytoxan

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关于此项目

经验公式(希尔记法):
C7H15Cl2N2O2P · H2O
化学文摘社编号:
分子量:
279.10
UNSPSC Code:
51112507
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-015-4
Beilstein/REAXYS Number:
4678992
MDL number:
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产品名称

环磷酰胺 一水合物, ISOPAC®

InChI key

PWOQRKCAHTVFLB-UHFFFAOYSA-N

InChI

1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

SMILES string

[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1

assay

97.0-103.0% (HPLC)

form

powder

mp

49-51 °C (lit.)

storage temp.

2-8°C

Quality Level

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Application

环磷酰胺是氮芥类烷化剂,被广泛用于抗肿瘤和抗免疫药物的作用机理研究。

Biochem/physiol Actions

广泛用于癌症化疗的细胞毒性氮芥衍生物。它可与 DNA 交联、导致链断裂并诱导突变。
环磷酰胺是一种广泛用于癌症化疗的具有细胞毒性的氮芥衍生物。它可与 DNA 交联、导致链断裂并诱导突变。其临床活性与乙醛脱氢酶 1 (ALDH1) 的活性降低相关。

Disclaimer

将相容溶剂直接注入小瓶中,可制备任何所需规格的溶液,无需暴露。

Packaging

包装在 100 mL 血清瓶中,具有硅/PTFE 隔膜和铝封。

Preparation Note

将内容物溶于 100 mL 溶剂中,得到 1% 溶液。

Legal Information

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

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Lupus nephritis remains one of the most severe manifestations of systemic lupus erythematosus associated with considerable morbidity and mortality. A better understanding of the pathogenesis of lupus nephritis is an important step in identifying more targeted and less toxic therapeutic
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Currently, amino-terminal PEGylated human granulocyte colony stimulating factor (huG-CSF) is used to prevent and treat neutropenia. Although huG-CSF has been used as a drug for more than 20 years, it has three significant drawbacks: (i) it relies on PEG aldehyde
Leo Luznik et al.
Seminars in oncology, 39(6), 683-693 (2012-12-05)
Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative therapy for many hematologic and immunologic diseases. Further, partial or full donor hematopoietic chimerism following alloSCT may be sufficient to guarantee immunologic tolerance to solid organs from the same donor
Parotitis as the presenting symptom of Wegener's granulomatosis: case report and meta-analysis.
Ilan Green et al.
The Israel Medical Association journal : IMAJ, 15(3), 188-192 (2013-05-15)

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Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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