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类型
Type V
表单
lyophilized powder
效能
≤64 μg per mL agglutination activity
杂质
Carbohydrate, essentially free
salt, essentially free
≤0.16 wt. % Ca
≤0.23 wt. % Mn
储存温度
−20°C
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生化/生理作用
刀豆素 A 无血型特异性，但对末端 α-D-甘露糖基和 α-D-葡糖基残基具有亲和力。需要 Ca2+ 和 Mn2+ 离子存在才能显示活性。刀豆素 A 在 pH 6.5 或更低的条件下解离为二聚体。pH 在 5.8 至 7.0 之间时，刀豆素 A 以四聚体形式存在；pH 高于 7.0 时，形成更高的聚合体。根据聚合程度不同，刀豆素 A 可能显示出具有促有丝分裂的活性。琥珀酰化可以生成一种能够在 pH 高于 5.6 时仍保持二聚体形式的活性二聚体。
质量
Highly purified.
制备说明
Produced from whole Jack beans (J0250) using the method of Sophianopoulos.
分析说明
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.
警示用语：
Danger
危险声明
危险分类
Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
Guanbin Gao et al.
Traffic (Copenhagen, Denmark), 21(3), 274-296 (2019-12-29)
Protein retention and the transport of proteins and lipids into and out of the Golgi is intimately linked to the biogenesis and homeostasis of this sorting hub of eukaryotic cells. Of particular importance are membrane proteins that mediate membrane fusion
A J Sophianopoulos et al.
Preparative biochemistry, 11(4), 413-435 (1981-01-01)
Concanavalin A (Con A), obtained either commercially or by affinity chromatography, was further purified by incubating at 6-8 hr at pH 3.0-3.2 in 1 M NaCl, 0.08 M glycine and 3 mM each Ca2+ and Mn+2, heat treating at 45
Yeo Reum Park et al.
Journal of microbiology and biotechnology, 28(12), 2106-2112 (2018-11-02)
Concanavalin A (ConA) interacts with carbohydrates as a lectin, and recent reports proposed its application for detecting a diversity of viruses and pathogens. Structural studies have detailed the interaction between ConA and carbohydrates and the metal coordination environment with manganese
Gustavo Vasen et al.
Communicative & integrative biology, 13(1), 128-139 (2020-10-06)
Chemotactic/chemotropic cells follow accurately the direction of gradients of regulatory molecules. Many G-protein-coupled receptors (GPCR) function as chemoattractant receptors to guide polarized responses. In "a" mating type yeast, the GPCR Ste2 senses the α-cell's pheromone. Previously, phosphorylation and trafficking of
Masak Takaine et al.
Journal of cell science, 132(8) (2019-03-13)
Adenosine triphosphate (ATP) is a main metabolite essential for all living organisms. However, our understanding of ATP dynamics within a single living cell is very limited. Here, we optimized the ATP-biosensor QUEEN and monitored the dynamics of ATP with good
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