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About This Item
经验公式（希尔记法）:
C16H12N2 · xH2O
CAS号:
分子量:
232.28 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98% (HPLC)
表单
powder
颜色
purple
溶解性
DMSO: ≥5 mg/mL
储存温度
2-8°C
SMILES字符串
O.Cn1c2ccccc2cc3nc4ccccc4c13
InChI
1S/C16H12N2.H2O/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14;/h2-10H,1H3;1H2
InChI key
AOTFRBDOIUZYCT-UHFFFAOYSA-N
生化/生理作用
Cryptolepine hydrate is a cytoxic, anti-cancer, antimalarial agent
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
João Lavrado et al.
Journal of medicinal chemistry, 54(3), 734-750 (2011-01-07)
The synthesis of cryptolepine derivatives containing basic side-chains at the C-11 position and their evaluations for antiplasmodial and cytotoxicity properties are reported. Propyl, butyl, and cycloalkyl diamine side chains significantly increased activity against chloroquine-resistant Plasmodium falciparum strains while reducing cytotoxicity
Arnold Donkor Forkuo et al.
BMC pharmacology & toxicology, 18(1), 84-84 (2017-12-24)
This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenous pharmacokinetics of cryptolepine in male
Olumayokun A Olajide et al.
Bioorganic & medicinal chemistry, 15(1), 43-49 (2006-10-27)
The alkaloid cryptolepine is thought to mediate the anti-inflammatory effects of the climbing shrub, Cryptolepis sanguinoleta. The underlying mechanism of action, however, is largely unknown. In the present study, we show that the synthetic cryptolepine-hydrochloride (2.5-10microM) dose-dependently inhibits lipopolysaccharide (LPS)-induced
Marta Rojas et al.
Antimicrobial agents and chemotherapy, 52(11), 3844-3850 (2008-08-20)
We have used the budding yeast Saccharomyces cerevisiae to identify genes that may confer sensitivity in vivo to the antimalarial and cytotoxic agent cryptolepine. Five S. cerevisiae strains, with different genetic backgrounds in cell permeability and DNA damage repair mechanisms
Harish C Pal et al.
Scientific reports, 7(1), 1498-1498 (2017-05-06)
Dysregulated mitochondrial dynamics and biogenesis have been associated with various pathological conditions including cancers. Here, we assessed the therapeutic effect of cryptolepine, a pharmacologically active alkaloid derived from the roots of Cryptolepis sanguinolenta, on melanoma cell growth. Treatment of human
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