所有图片(1)
别名:
5-Methyl-5H-quindoline hydrate
经验公式（希尔记法）:
C16H12N2 · xH2O
CAS号:
分子量:
232.28 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
检测方案
≥98% (HPLC)
形式
powder
颜色
purple
溶解性
DMSO: ≥5 mg/mL
储存温度
2-8°C
SMILES字符串
O.Cn1c2ccccc2cc3nc4ccccc4c13
InChI
1S/C16H12N2.H2O/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14;/h2-10H,1H3;1H2
InChI key
AOTFRBDOIUZYCT-UHFFFAOYSA-N
生化/生理作用
Cryptolepine hydrate is a cytoxic, anti-cancer, antimalarial agent
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
João Lavrado et al.
Journal of medicinal chemistry, 54(3), 734-750 (2011-01-07)
The synthesis of cryptolepine derivatives containing basic side-chains at the C-11 position and their evaluations for antiplasmodial and cytotoxicity properties are reported. Propyl, butyl, and cycloalkyl diamine side chains significantly increased activity against chloroquine-resistant Plasmodium falciparum strains while reducing cytotoxicity
Arnold Donkor Forkuo et al.
BMC pharmacology & toxicology, 18(1), 84-84 (2017-12-24)
This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenous pharmacokinetics of cryptolepine in male
Rajendran C Gopalan et al.
Toxicology letters, 207(3), 322-325 (2011-09-29)
Malaria is a mosquito-borne infectious disease caused by the genus Plasmodium. It causes one million deaths per year in African children under the age of 5 years. There is an increasing development of resistance of malarial parasites to chloroquine and
Louise R Whittell et al.
Bioorganic & medicinal chemistry, 19(24), 7519-7525 (2011-11-08)
A series of mono- and di-substituted analogues of isocryptolepine have been synthesized and evaluated for in vitro antimalarial activity against chloroquine sensitive (3D7) and resistant (W2mef) Plasmodium falciparum and for cytotoxicity (3T3 cells). Di-halogenated compounds were the most potent derivatives
Hadi Behzadi et al.
Journal of molecular modeling, 17(12), 3289-3297 (2011-03-04)
Density functional theory calculations were applied to investigate (13)C chemical shielding tensors in cryptolepine and its bromo-substituted analogs, 2-bromocryptolepine and 2,7-dibromocryptolepine. The fact that bromo-substituted cryptolepine shows higher antiplasmodial activity than cryptolepine raises the question of whether this effect can
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