所有图片(2)
About This Item
经验公式（希尔记法）:
C9H11ClN2O5
CAS号:
分子量:
262.65
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
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质量水平
方案
≥98% (HPLC)
表单
powder
溶解性
1 M NH4OH: 20 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Cl)C(=O)NC2=O
InChI
1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key
NJCXGFKPQSFZIB-RRKCRQDMSA-N
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应用
5-氯-2′-脱氧尿苷已用于：
- 利用动物模型，通过免疫组化分析和双S期标记研究细胞周期动力学
- 使用动物模型分析细胞周期长度
- 标记HEK293T细胞进行分子梳理试验
生化/生理作用
用5-氯-2′-脱氧尿苷(CldU)标记的DNA是分析和量化DNA复制、修复和重组的有效工具。CldU是一种有效的诱变剂、分裂剂和毒物。它被用作胸腺嘧啶类似物，并被发现改变dNTP池，可能导致细胞周期停滞。CldU产生姐妹染色单体交换，但与其他胸腺嘧啶类似物相比，对电离辐射的响应较小。5-氯-2′-脱氧尿苷（CldU，氯脱氧尿苷）用于研究DNA和DNA前体的次氯酸损伤引起碱基错配的潜在可能。在识别DNA复制位点的实验方案中，5-氯-2′-脱氧尿苷(CldU)可掺入DNA以便通过CldU抗体进行后续的免疫荧光成像。氯脱氧尿苷可与其他卤化尿苷，如碘脱氧尿苷(IdU)，共同作为标记底物使用。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Beatrice Rondinelli et al.
Nature cell biology, 19(11), 1371-1378 (2017-10-17)
The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1/2-deficient cancers.
Mary Youssef et al.
Scientific reports, 9(1), 4120-4120 (2019-03-13)
Early life stress predisposes to mental illness and behavioral dysfunction in adulthood, but the mechanisms underlying these persistent effects are poorly understood. Stress throughout life impairs the structure and function of the hippocampus, a brain system undergoing considerable development in
Jerry H Houl et al.
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Poly(ADP-ribose)ylation (PARylation) by PAR polymerase 1 (PARP1) and PARylation removal by poly(ADP-ribose) glycohydrolase (PARG) critically regulate DNA damage responses; yet, conflicting reports obscure PARG biology and its impact on cancer cell resistance to PARP1 inhibitors. Here, we found that PARG
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