推荐产品
生物来源
bovine cartilage
质量水平
等级
standard (for CPC (cetylpyridinium chloride) titration)
检测方案
98-102% (CPC, titration)
形式
powder
旋光性
[α]20/D -30 to -20 °, c = 5% (w/v) in water
杂质
<10.0% water (Karl Fischer)
颜色
white to off-white
溶解性
H2O: soluble 50 mg/mL, clear to hazy, colorless to faintly yellow
痕量阳离子
Na: 7.4-8.8% (anhydrous)
储存温度
2-8°C
SMILES字符串
[Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]2O[C@@H]([C@H](O)[C@@H](O)[C@@H]2O)C(O)=O
一般描述
软骨素是一种氨基葡萄糖聚糖 (GAG)，是 N-乙酰半乳糖胺 (GalNAc) 和葡萄糖醛酸 (GlcA) 交替单位组成的多糖链，可在 GalNAc 和/或GlcA 单位上发生硫酸化。软骨素及其硫酸盐经常附着在蛋白质上形成蛋白聚糖。
应用
硫酸软骨素是由 N-乙酰半乳糖胺 (GalNAc) 和葡萄糖醛酸 (GlcA) 交替组成的氨基葡聚糖 (GAG) 多糖链，广泛用于包括生物工程在内的多个研究领域。硫酸软骨素可作为生物材料共聚物或表面衍生试剂用于药物释放载体、组织工程装置和生物支架的开发。硫酸软骨素可用于开发生物相容性结构，如水凝胶、海绵、生物膜、微球和胶束等。
生化/生理作用
硫酸软骨素分子作为一种体积大、带负电荷的亲水性分子，由于灵活性差无法折叠成紧凑的球状结构。它可形成多孔水合凝胶，为组织提供机械支撑，并允许水溶性分子的快速扩散和细胞的迁移。
组分
软骨素是一种酸性粘多糖，存在于软骨、皮肤、角膜和脐带中。由等摩尔量的交替 N-乙酰半乳糖胺、D-葡萄糖醛酸和硫酸盐残基组成，可在其任一亚基上硫酸化。硫酸化可发生在半乳糖胺部分的 6 位和/或 4 位，任何单个二糖单位都可能是 6-硫酸化、4-硫酸化、4,6-二硫酸化或未硫酸化。
注意
本品应在 2-8℃ 下储存。
制备说明
本品在水中溶解度为 100 mg/mL。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Determination of the chondroitin sulfate disaccharides in dog and horse plasma by HPLC using chondroitinase digestion, precolumn derivatization, and fluorescence detection.
Du J, Eddington N.
Analytical Biochemistry, 306, 252-258 (202)
Feng Wang et al.
Acta biomaterialia, 6(6), 1978-1991 (2009-12-17)
A family of injectable, rapid gelling and highly flexible hydrogel composites capable of releasing insulin-like growth factor (IGF-1) and delivering mesenchymal stromal cell (MSC) were developed. Hydrogel composites were fabricated from Type I collagen, chondroitin sulfate (CS) and a thermosensitive
Satoshi Uchida et al.
Journal of controlled release : official journal of the Controlled Release Society, 155(2), 296-302 (2011-05-17)
Nonviral polycation-based gene carriers (polyplexes) have attracted attention as safe and efficient gene delivery systems. Polyplex micelles comprised of poly(ethyleneglycol)-block-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (PEG-PAsp(DET)) and plasmid DNA (pDNA) have shown high transfection efficiency with low toxicity due to the pH-sensitive protonation behavior of
Zhongming Liang et al.
Journal of pharmaceutical and biomedical analysis, 28(2), 245-249 (2002-04-04)
A photometric titration method was developed and validated to quantitate sodium chondroitin sulfate in raw materials and Cosequin DS chewable tablet(1). About 0.1% (w/v) cetylpyridinium chloride was used to titrate sodium chondroitin sulfate with photometric indication at wavelength 420 nm.
Maelene L Wong et al.
Acta biomaterialia, 9(5), 6492-6501 (2013-01-17)
The ability of residual antigens on decellularized tissue to elicit the immune response upon implantation motivates development of a more rigorous antigen removal (AR) process for xenogeneic scaffold generation. Antigen removal strategies promoting solubilization of hydrophilic proteins (predominantly cytoplasmic) enhance
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门