形式
liquid
质量水平
颜色
clear colorless
密度
1.14 g/mL at 25 °C (lit.)
创始人
Wyeth
储存温度
2-8°C
SMILES字符串
CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
InChI
1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChI key
KNHUKKLJHYUCFP-UHFFFAOYSA-N
基因信息
human ... PPARA(5465)
mouse ... Ppara(19013)
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应用
Clofibrate has been used:
- as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
- as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
- as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes
生化/生理作用
Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.
特点和优势
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Drug treatment of lipid disorders.
R H Knopp
The New England journal of medicine, 341(7), 498-511 (1999-08-12)
K Nadira De Abrew et al.
Toxicology, 328, 29-39 (2014-12-06)
High-content data have the potential to inform mechanism of action for toxicants. However, most data to support this notion have been generated in vivo. Because many cell lines and primary cells maintain a differentiated cell phenotype, it is possible that
Masayuki Yoshikawa et al.
Journal of natural products, 68(9), 1360-1365 (2005-09-27)
The methanolic extract and its n-butanol-soluble fraction from the flowers of the tea plant (Camellia sinensis) were found to suppress serum triglyceride elevation in olive oil-treated mice. From the n-butanol-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, floratheasaponins A-C (1-3)
Sara Chuang et al.
Journal of medicinal chemistry, 52(17), 5344-5355 (2009-08-12)
Liver-fatty acid binding protein (L-FABP) is found in high levels in enterocytes and is involved in cytosolic solubilization of fatty acids. In addition, L-FABP has been shown to bind endogenous and exogenous lipophilic compounds, suggesting that it may also play
Szu-Han Chen et al.
PloS one, 12(11), e0187507-e0187507 (2017-11-03)
We tested the hypothesis that prenatal administration of PPARα agonist clofibrate may permanently increase browning capacity of developing white adipose tissue (WAT). Pregnant C57BL/6J mice were fed a basal diet, without (C) or with 0.5% clofibrate (CF, a PPARα agonist)
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