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表单
liquid crystal
质量水平
SMILES字符串
[H][C@@]([C@H](C)CCCC(C)C)([C@@]1(C)CC[C@@]23[H])CC[C@]1([C@](CC=C4C[C@H](CC[C@]34C)OC(CCC(O)=O)=O)2[H])[H]
InChI
1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1
InChI key
WLNARFZDISHUGS-MIXBDBMTSA-N
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一般描述
胆固醇半琥珀酸酯（CHEMS）是一种酸性胆固醇酯。它在碱性和中性水性介质中自组装成双分子层。CHEMS表现出pH敏感性聚合。它由琥珀酸与胆固醇的β-羟基发生酯化反应而形成。这种化学修饰使CHEMS能够在合适的水性介质中进行薄层组装，而胆固醇在水性环境中形成一水合物晶体。
应用
- Experimental determination and computational interpretation of biophysical properties of lipid bilayers enriched by Cholesteryl Hemisuccinate： 解析胆固醇琥珀酸单酯对磷脂双层的作用，加深了解其生物物理特性(W Kulig et al., 2015)。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Denitsa Momekova et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 32(4-5), 308-317 (2007-10-12)
A major hurdle towards in vivo utilization of pH-sensitive liposomes is their prompt sequestration by reticuloendothelial system and hence short circulation time. Prolonged circulation of liposomes is usually achieved by incorporation of pegylated lipids, which have been frequently reported to
Zhe Zhang et al.
eLife, 7 (2018-05-11)
Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat control. TRPM2 is activated by cytosolic Ca2+, phosphatidyl-inositol-4,5-bisphosphate and ADP ribose. Here, we present the ~3 Å resolution electron
Julia Lehtinen et al.
Journal of controlled release : official journal of the Controlled Release Society, 131(2), 145-149 (2008-08-12)
Cationic polymers are efficient gene delivery vectors in in vitro conditions, but these carriers can fail in vivo due to interactions with extracellular polyanions, i.e. glycosaminoglycans (GAG). The aim of this study was to develop a stable gene delivery vector
Y Yamamoto et al.
Plant physiology, 67(6), 1069-1072 (1981-06-01)
Cholesteryl hemisuccinate has been incorporated into pea chloroplast thylakoids to investigate the relationship between fluidity and functioning of this membrane system. Levels of sterol which increased the apparent viscosity of the membrane, estimated by fluorescence polarization measurements using the lipophilic
Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior.
Hafez IM and Cullis PR
Biochim. Biophys. Acta Gen. Subj., 1463(1), 107-114 (2000)
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