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C6512

胆甾醇半琥珀酸酯

Name: 胆甾醇半琥珀酸酯
Brand: SIGMA

别名:

3β-Hydroxy-5-cholestene 3-hemisuccinate, 胆固醇半琥珀酸酯, 胆甾醇琥珀酸酯

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关于此项目

经验公式（希尔记法）:

C₃₁H₅₀O₄

化学文摘社编号:

1510-21-0

分子量:

486.73

NACRES:

NA.23

PubChem Substance ID:

24892873

UNSPSC Code:

12352103

EC Number:

216-148-6

MDL number:

MFCD00037705

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属性

form

liquid crystal

Quality Level

200

SMILES string

[H][C@@]([C@H](C)CCCC(C)C)([C@@]1(C)CC[C@@]23[H])CC[C@]1([C@](CC=C4C[C@H](CC[C@]34C)OC(CCC(O)=O)=O)2[H])[H]

InChI

1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1

InChI key

WLNARFZDISHUGS-MIXBDBMTSA-N

说明

General description

胆固醇半琥珀酸酯（CHEMS）是一种酸性胆固醇酯。它在碱性和中性水性介质中自组装成双分子层。CHEMS表现出pH敏感性聚合。它由琥珀酸与胆固醇的β-羟基发生酯化反应而形成。这种化学修饰使CHEMS能够在合适的水性介质中进行薄层组装，而胆固醇在水性环境中形成一水合物晶体。

Application

Experimental determination and computational interpretation of biophysical properties of lipid bilayers enriched by Cholesteryl Hemisuccinate： 解析胆固醇琥珀酸单酯对磷脂双层的作用，加深了解其生物物理特性(W Kulig et al., 2015)。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior.

Hafez IM and Cullis PR

Biochim. Biophys. Acta Gen. Subj., 1463(1), 107-114 (2000)

Long-circulating, pH-sensitive liposomes sterically stabilized by copolymers bearing short blocks of lipid-mimetic units.

Denitsa Momekova et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 32(4-5), 308-317 (2007-10-12)

A major hurdle towards in vivo utilization of pH-sensitive liposomes is their prompt sequestration by reticuloendothelial system and hence short circulation time. Prolonged circulation of liposomes is usually achieved by incorporation of pegylated lipids, which have been frequently reported to

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.

Zhe Zhang et al.

eLife, 7 (2018-05-11)

Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat control. TRPM2 is activated by cytosolic Ca2+, phosphatidyl-inositol-4,5-bisphosphate and ADP ribose. Here, we present the ~3 Å resolution electron

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全球贸易项目编号

货号	GTIN
C6512-5G	04061833511329
C6512-25G	04061833511312