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Merck
CN

C6506

4-氯-DL-苯丙氨酸

greener alternative

5-HT synthesis inhibitor, solid

别名:

PCP, PCPA

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关于此项目

线性分子式:
ClC6H4CH2CH(NH2)CO2H
化学文摘社编号:
7424-00-2
分子量:
199.63
NACRES:
NA.32
PubChem Substance ID:
24278081
UNSPSC Code:
12352209
EC Number:
231-051-9
MDL number:
MFCD00002601

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产品名称

4-氯-DL-苯丙氨酸,

InChI

1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)

InChI key

NIGWMJHCCYYCSF-UHFFFAOYSA-N

SMILES string

NC(Cc1ccc(Cl)cc1)C(O)=O

form

solid

greener alternative product score

old score: 2
new score: 1
Find out more about DOZN™ Scoring

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

>240 °C (dec.) (lit.)

greener alternative category

, Re-engineered

storage temp.

room temp

Quality Level

100

Gene Information

human ... TPH1(7166), TPH2(121278)

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相关类别

Application

4-氯-DL-苯丙氨酸用于：
  • 作为色氨酸羟化酶1（TPH1）抑制剂，处理 kras+ 雄性斑马鱼
  • 在大鼠模型中诱发失眠
  • 处理胚胎，检查其对5-羟色胺的影响
  • 选择带 pESentA32质粒的粪肠球菌（ Enterococcus faecalis ）转化体
  • 饲喂苍蝇，研究5-羟色胺的作用

Biochem/physiol Actions

4-氯-DL-苯丙氨酸（PCPA）是5-羟色胺（5-HT）合成抑制剂。有助于改善肺部组织炎症和重塑肺动脉。PCPA 可减少色氨酸羟化酶1（TPH1）、基质金属蛋白酶（MMP）和促炎因子的表达。
色氨酸羟化酶抑制剂。

General description

我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品属于重新设计产品类别，在“危险性较小的化学合成”、“设计更安全的化学品和产品”和“节能设计”绿色化学原则方面取得了重大改进。 点击此处查看其 DOZN 记分卡。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SHBT1902
SHBR7239
SHBQ3488
SHBM8911
SHBM3004

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