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Merck
CN

C6506

4-氯-DL-苯丙氨酸

greener alternative

5-HT synthesis inhibitor, solid

别名:

PCP, PCPA

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关于此项目

线性分子式:
ClC6H4CH2CH(NH2)CO2H
化学文摘社编号:
7424-00-2
分子量:
199.63
EC 号:
231-051-9
MDL编号:
MFCD00002601
UNSPSC代码:
12352209
PubChem化学物质编号:
24278081
NACRES:
NA.32

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产品名称

4-氯-DL-苯丙氨酸,

表单

solid

质量水平

100

环保替代产品得分

old score: 2
new score: 1
Find out more about DOZN™ Scoring

环保替代产品特性

Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

>240 °C (dec.) (lit.)

环保替代产品分类

, Re-engineered

储存温度

room temp

SMILES字符串

NC(Cc1ccc(Cl)cc1)C(O)=O

InChI

1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)

InChI key

NIGWMJHCCYYCSF-UHFFFAOYSA-N

基因信息

human ... TPH1(7166), TPH2(121278)

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相关类别

一般描述

我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品属于重新设计产品类别，在“危险性较小的化学合成”、“设计更安全的化学品和产品”和“节能设计”绿色化学原则方面取得了重大改进。 点击此处查看其 DOZN 记分卡。

应用

4-氯-DL-苯丙氨酸用于：
  • 作为色氨酸羟化酶1（TPH1）抑制剂，处理 kras+ 雄性斑马鱼
  • 在大鼠模型中诱发失眠
  • 处理胚胎，检查其对5-羟色胺的影响
  • 选择带 pESentA32质粒的粪肠球菌（ Enterococcus faecalis ）转化体
  • 饲喂苍蝇，研究5-羟色胺的作用

生化/生理作用

4-氯-DL-苯丙氨酸（PCPA）是5-羟色胺（5-HT）合成抑制剂。有助于改善肺部组织炎症和重塑肺动脉。PCPA 可减少色氨酸羟化酶1（TPH1）、基质金属蛋白酶（MMP）和促炎因子的表达。
色氨酸羟化酶抑制剂。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301,H317

危险分类

Acute Tox. 3 Oral - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SHBT1902
SHBR7239
SHBQ3488
SHBM8911
SHBM3004

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Frederic D L Leusch et al.
Chemosphere, 191, 868-875 (2017-11-07)
Environmental chemicals can induce thyroid disruption through a number of mechanisms including altered thyroid hormone biosynthesis and transport, as well as activation and inhibition of the thyroid receptor. In the current study six in vitro bioassays indicative of different mechanisms of
Hadas Tsivion-Visbord et al.
Translational psychiatry, 10(1), 305-305 (2020-09-03)
Schizophrenia is a debilitating psychiatric disorder with a significant number of patients not adequately responding to treatment. Phencyclidine (PCP) is used as a validated model for schizophrenia, shown to reliably induce positive, negative and cognitive-like behaviors in rodents. It was
PCPA protects against monocrotaline-induced pulmonary arterial remodeling in rats: potential roles of connective tissue growth factor
Bai Y, et al.
Testing, 8(67), 111642-111642 (2017)
Mariana G Fronza et al.
PloS one, 12(11), e0187445-e0187445 (2017-11-02)
A series of phenylselanyl-1H-1,2,3-triazole-4-carbonitriles with different substituents were screened for their binding affinity with serotonin transporter (SERT) and dopamine transporter (DAT) by docking molecular. 5-(4methoxyphenyl)-1-(2-(phenylselanyl)phenyl)-1H-1,2,3-triazole-4-carbonitrile (SeTACN) exhibited the best conformation with SERT even higher than fluoxetine and serotonin, suggesting a
Enhancement of the antibacterial activity of an E. faecalis strain by the heterologous expression of enterocin A
Serrano-Maldonado C E and Quirasco M
Journal of Biotechnology, 283(5), 28-36 (2018)
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