C6499
CTB
≥98% (HPLC)
别名:
CTPB, N-（4-氯-3-三氟甲基-苯基）-2-乙氧基-苯甲酰胺
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关于此项目
经验公式（希尔记法）:
C16H13ClF3NO2
化学文摘社编号:
分子量:
343.73
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
CTB, ≥98% (HPLC)
InChI key
YDXZSNHARVUYNM-UHFFFAOYSA-N
SMILES string
FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Application
CTB 已用于研究其P53 蛋白乙酰化的凋亡作用。
Biochem/physiol Actions
CBP（CREB 结合蛋白）/p300）组蛋白乙酰转移酶 (HAT) 激活剂；p300 HAT 激活器。
CTPB 是第一个已知的组蛋白乙酰转移酶 p300 的小分子激活剂。CTB 是 CTPB 的一种简化类似物，具有相当或更高的活性。该化合物激活 p300/EP300/E1A 结合蛋白的组蛋白乙酰转移酶 (HAT) 活性。
HAT 的小分子激活剂如 CTB（N-（4-氯-3-三氟甲基-苯基）-2-乙氧基-苯甲酰胺）可直接改变染色质乙酰化。可作为治疗神经精神、神经发育和神经退行性疾病等认知功能障碍并发症的药物。
Features and Benefits
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
General description
CTB（N-（4-氯-3-三氟甲基-苯基）-2-乙氧基-苯甲酰胺）来源于漆树酸。
存储类别
11 - Combustible Solids
wgk
WGK 2
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Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is evidence that increased release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α) contributes to the development of the hypertension, but the underlying neural mechanisms are
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DeMetris D Reed et al.
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Palatability attributes of beef striploin steaks mechanically enhanced with pork fat were evaluated. Striploins were collected from USDA Standard steer carcasses, longitudinally cut into halves (lateral or medial) and assigned randomly to pork fat injection (PFI) or non-injected control (CON).
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