推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~56 kDa
种属反应性
human
技术
western blot: 1:500-1:1,000
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CYP26A1(1592)
一般描述
Cytochrome P450 26A1 is a protein encoded by the CYP26A1 gene in humans. It is mapped on human chromosome 10q23-q24. CYP26A1 gene encodes cytochrome P450 enzyme, specifically involved in metabolic inactivation of retinoic acid (RA).
免疫原
synthetic peptide corresponding to amino acids 481-495 of human CYP26A1
应用
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CYP26A1 (481-495) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:1,000.
生化/生理作用
CYP26A1 promotes cell survival properties and contributes to the carcinogenic process. Enhanced CYP26A1 expression causes a functional Vitamin A deficiency (VAD) state in skin that leads to neoplastic transformation of keratinocytes in an early phase during skin carcinogenesis. It has high ligand selectivity but accepts structurally related nuclear receptor agonists as inhibitors. CYP26A1 is the P450 isoform and can be targeted when designing retinoic acid (RA) metabolism blocking agents.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3.
J A White et al.
Genomics, 48(2), 270-272 (1998-04-02)
Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase.
Jayne E Thatcher et al.
Molecular pharmacology, 80(2), 228-239 (2011-04-28)
All-trans-retinoic acid (atRA) is the active metabolite of vitamin A. atRA is also used as a drug, and synthetic atRA analogs and inhibitors of retinoic acid (RA) metabolism have been developed. The hepatic clearance of atRA is mediated primarily by
Jayne E Thatcher et al.
Biochemical pharmacology, 80(6), 903-912 (2010-06-02)
All-trans retinoic acid (RA) is a critical signaling molecule and its concentration is tightly regulated. Several P450 enzymes including CYP26A1, CYP2C8, and CYP3A4 have been proposed to be responsible for RA clearance in the liver but their quantitative importance has
Makoto Osanai et al.
Medical molecular morphology, 44(4), 200-206 (2011-12-20)
Vitamin A deficiency (VAD) is associated with increased susceptibility to carcinogenesis. CYP26A1, the gene encoding a cytochrome P450 enzyme specifically involved in metabolic inactivation of retinoic acid (RA), the most active vitamin A derivative, has been shown to result in
John-Poul Ng-Blichfeldt et al.
Thorax, 72(6), 510-521 (2017-01-15)
Molecular pathways that regulate alveolar development and adult repair represent potential therapeutic targets for emphysema. Signalling via retinoic acid (RA), derived from vitamin A, is required for mammalian alveologenesis, and exogenous RA can induce alveolar regeneration in rodents. Little is
商品
一期生物转化反应在药物上引入或暴露官能团，目的是增加化合物的极性。尽管一期药物代谢发生在大多数组织中，但代谢的主要和首过部位发生在肝循环期间。
Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.
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