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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
LDS-68, monoclonal
包含
15 mM sodium azide
种属反应性
human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:200 using formalin-fixed, paraffin-embedded sections of human and animal tissue
microarray: suitable
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... KRT7(3855)
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一般描述
Keratin, type II cytoskeletal 7 is a protein encoded by the KRT7 gene in humans. It is also known as cytokeratin-7 (CK-7), keratin-7 (K7), sarcolectin (SCL) and K2C7. Keratin 7 is a type II keratin and is a member of the keratin gene family. It is found on chromosome 12. It is specifically expressed in the simple epithelia lining of the internal organs and in the gland ducts as well as blood vessels.
Monoclonal anti-Cytokeratin Peptide 7 (mouse IgG1 isotype) is derived from the hybridoma produced the fusion of mouse myeloma cells and splenocytes of an immunized mouse. Cytokeratins are the intermediate filaments of endocrine cells. These proteins belongs to the intermediate filament (10 nm) superfamily of cytoskeletal proteins. Cytokeratin 7 (CK 7/ KRT7) is a low molecular weight cytokeratin. It is present in epithelial tissues of lung, breast and ovary.
特异性
The antibody reacts specifically with most simple epithelia but shows no reaction with epithelial cells in the intestine or in the stomach.
免疫原
cytoskeletal preparation of the RT4 human bladder carcinoma cell line.
应用
Monoclonal Anti-Cytokeratin Peptide 7 antibody produced in mouse has been used in:
- immunohistochemical staining
- western blotting
- immunohistochemistry
- immunofluorescence.
生化/生理作用
Cytokeratins may play an important role in transhepatic transport and canalicular secretion. Cytokeratin 7 (CK 7/ KRT7) only stains bile ducts in normal liver, hence it is considered as “bile duct keratin”. CK 7 is widely used in surgical pathology. It acts as a specific marker for mammary and extramammary Paget′s disease.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Brush biopsy of human oral mucosal epithelial cells as a quality control of the cell source for fabrication of transplantable epithelial cell sheets for regenerative medicine
Kasai Y, et al.
Regenerative therapy, 4, 71-77 (2016)
Immunohistology of endocrine tumors
Diagnostic Immunohistochemistry (Masson Publishing), 291-339 (2010)
Yoshiyuki Kasai et al.
Regenerative therapy, 4, 71-77 (2016-03-24)
Autologous oral mucosal epithelial cell sheets have been used for treating epithelial defects such as cornea and esophagus. The cell source of patients' oral mucosal epithelial cell sheet should be examined in normality because it has individual difference. In this
Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies.
Offord EA, et al.
Investigative Ophthalmology & Visual Science, 40(6), 1091-1101 (1999)
Hirohiko Iwatsuki et al.
Acta histochemica et cytochemica, 40(4), 123-130 (2007-09-28)
The expression of intermediate filaments is sensitively reflected in cell function. To examine the involvement of keratin in a secretory function, 15 kinds of keratin (keratin-2, 3, 4, 5, 6, 7, 8, 10, 13, 14, 16, 17, 18, 19, 20)
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