所有图片(1)
About This Item
经验公式（希尔记法）:
C44H38O14
CAS号:
分子量:
790.76
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
生物来源
microbial (Cladosporium cladosporioides)
质量水平
检测方案
≥90% (HPLC)
形式
powder
颜色
red to brown
溶解性
DMF: 1 mg/mL
DMSO: 1 mg/mL
ethanol: 1 mg/mL
储存温度
−20°C
SMILES字符串
COc1cc(O)c2C(=O)C(OC)=C(CC(C)OC(=O)Oc3ccc(O)cc3)c4c5C(CC(C)OC(=O)c6ccccc6)=C(OC)C(=O)c7c(O)cc(OC)c(c57)c1c24
InChI
1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3
InChI key
SRJYZPCBWDVSGO-UHFFFAOYSA-N
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
E Kobayashi et al.
Biochemical and biophysical research communications, 159(2), 548-553 (1989-03-15)
Calphostin C (UCN-1028C), a newly isolated compound from Cladosporium cladosporioides, is a potent and specific inhibitor of protein kinase C, because it was 1000 times more inhibitory to protein kinase C (IC50, 0.05 microM) than other protein kinases such as
H Ikemoto et al.
Journal of neurosurgery, 83(6), 1008-1016 (1995-12-01)
Calphostin C acts at the regulatory domain as a highly selective inhibitor of protein kinase C (PKC), and staurosporine acts at the catalytic domain as a nonspecific PKC inhibitor. The authors investigated the capacity of calphostin C and staurosporine to
I Ozaki et al.
The Journal of biological chemistry, 274(9), 5310-5317 (1999-02-20)
Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3
Yang Chen et al.
Annals of translational medicine, 10(3), 132-132 (2022-03-15)
The currently available treatment methods are ineffective in reducing mortality or improving outcomes in acute lung injury (ALI). The activation of protein kinase C alpha (PKCα) has recently been implicated in ALI development. We explored the potential therapeutic outcomes of
R F Bruns et al.
Biochemical and biophysical research communications, 176(1), 288-293 (1991-04-15)
Calphostin C, a secondary metabolite of the fungus Cladosporium cladosporioides, inhibits protein kinase C by competing at the binding site for diacylglycerol and phorbol esters. Calphostin C is a polycyclic hydrocarbon with strong absorbance in the visible and ultraviolet ranges.
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