C6240
CITCO
≥98% (HPLC), androstane receptor agonist, solid
别名:
6-（4-氯苯基）咪唑并[2，1-b][1，3]噻唑-5-甲醛O-（3，4-二氯苄基）肟
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关于此项目
经验公式（希尔记法）:
C19H12N3OCl3S
化学文摘社编号:
分子量:
436.74
MDL编号:
UNSPSC代码:
12352203
PubChem化学物质编号:
NACRES:
NA.77
产品名称
CITCO, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
溶解性
DMSO: soluble 28 mg/mL
H2O: insoluble
储存温度
−20°C
SMILES字符串
Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4
InChI
1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
InChI key
ZQWBOKJVVYNKTL-AUEPDCJTSA-N
相关类别
一般描述
CITCO是一种咪唑并噻唑衍生物。它刺激人类组成型雄烷受体（CAR）核易位。
应用
CITCO已用于小鼠组成型雄烷受体（CAR）和人CAR的激活。
生化/生理作用
CITCO是组成型雄烷受体（CAR）激动剂；核受体NR113激动剂。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
Maglich JM, et al.
The Journal of Biological Chemistry, 278(19), 17277-17283 (2003)
Won-Gu Choi et al.
Pharmaceutics, 12(3) (2020-03-07)
Mertansine, a tubulin inhibitor, is used as the cytotoxic component of antibody-drug conjugates (ADCs) for cancer therapy. The effects of mertansine on uridine 5'-diphospho-glucuronosyltransferase (UGT) activities in human liver microsomes and its effects on the mRNA expression of cytochrome P450s
Tadeja Režen et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 974-976 (2017-05-26)
Statins are well known lipid lowering agents that inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. They also activate drug metabolism but their exact receptor-mediated action has not been proven so far. We tested whether atorvastatin and rosuvastatin are direct ligands of
Susanne Johansson et al.
Clinical pharmacology in drug development, 6(5), 466-475 (2017-03-17)
Tenapanor (RDX5791, AZD1722) is an inhibitor of sodium/hydrogen exchanger isoform 3 in development for the treatment of constipation-predominant irritable bowel syndrome and the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis. We aimed to investigate whether tenapanor
Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
Chakraborty S , et al.
British Journal of Cancer, 104(3), 448-448 (2011)
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