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检测方案
≥98% (HPLC)
形式
solid
储存条件
desiccated
溶解性
DMSO: soluble 28 mg/mL
H2O: insoluble
储存温度
−20°C
SMILES字符串
Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4
InChI
1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
InChI key
ZQWBOKJVVYNKTL-AUEPDCJTSA-N
一般描述
CITCO是一种咪唑并噻唑衍生物。它刺激人类组成型雄烷受体（CAR）核易位。
应用
CITCO已用于小鼠组成型雄烷受体（CAR）和人CAR的激活。
生化/生理作用
CITCO是组成型雄烷受体（CAR）激动剂；核受体NR113激动剂。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
Maglich JM, et al.
The Journal of Biological Chemistry, 278(19), 17277-17283 (2003)
Tadeja Režen et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 974-976 (2017-05-26)
Statins are well known lipid lowering agents that inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. They also activate drug metabolism but their exact receptor-mediated action has not been proven so far. We tested whether atorvastatin and rosuvastatin are direct ligands of
Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
Chakraborty S , et al.
British Journal of Cancer, 104(3), 448-448 (2011)
Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss
Tschuor C, et l.
Journal of Hepatology, 65(1), 66-74 (2016)
Cristina Saez-Lopez et al.
Scientific reports, 7(1), 12284-12284 (2017-09-28)
Sex hormone-binding globulin (SHBG) carries sex steroids in blood regulating their bioavailability. Red wine consumption increases plasma SHBG levels, and we have discovered that resveratrol, a polyphenol enriched in red wine, acts specifically through the human constitutive androstane receptor (CAR)
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