C6116
(+/-)-氯前列醇钠盐水合物 钠盐 水合物
≥98% (HPLC), powder
别名:
7-[2-[4-(3-氯苯氧基)-3-羟基丁-1-烯基]-3,5-二羟基环戊基]庚-5-烯酸钠 钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C22H28ClNaO6 · xH2O
化学文摘社编号:
分子量:
446.90 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
259-439-3
NACRES:
NA.77
InChI
1S/C22H29ClO6.Na.H2O/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28;;/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28);;1H2/q;+1;/p-1/b3-1-,11-10+;;/t16-,18-,19-,20+,21-;;/m1../s1
InChI key
ZEQHRVULQBYULU-LPFHDDPUSA-M
SMILES string
[Na+].[H]O[H].O[C@@H](COc1cccc(Cl)c1)\C=C\[C@H]2[C@H](O)C[C@H](O)[C@@H]2C\C=C/CCCC([O-])=O
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
light brown
mp
68-70 °C
solubility
H2O: >10 mg/mL
storage temp.
−20°C
Quality Level
General description
氯前列醇是前列腺素F2α（PGF）的合成类似物。 氯前列醇有助于诱导动物发情，并具有子宫收缩作用。氯前列醇会诱发动物流产。
Application
(+/-)-氯前列醇钠盐水合物已用于研究其对小鼠发情同期和子宫发育的影响。
Biochem/physiol Actions
氯前列醇是一种有效的FP前列腺素类受体激动剂。
氯前列醇是一种有效的FP前列腺素类受体激动剂。与氟前列醇相比，氯前列醇更有效，但选择性较低。对于EP和TP前列腺素受体，氯前列醇与PGF2α 的效力相近。它可用于治疗母猪和小母猪的不孕症。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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X Valldecabres-Torres et al.
Journal of dairy science, 96(3), 1647-1652 (2013-01-15)
The 6-d timed artificial insemination protocol has been designed to advance luteolysis after the first administration of GnRH so that the preovulatory follicular diameter at second GnRH is reduced and thereby pregnancy outcome may be improved. To achieve an earlier
New estrus synchronization and artificial insemination protocol for goats based on male exposure, progesterone and cloprostenol during the non-breeding season
Lopez-Sebastian A, et al.
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Fanny E Volat et al.
Diabetes, 61(11), 2796-2806 (2012-08-02)
Negative regulators of white adipose tissue (WAT) expansion are poorly documented in vivo. Prostaglandin F(2α) (PGF(2α)) is a potent antiadipogenic factor in cultured preadipocytes, but evidence for its involvement in physiological context is lacking. We previously reported that Akr1b7, an
Soner Demirel et al.
Ocular immunology and inflammation, 21(1), 13-18 (2013-01-18)
To investigate the toxic-inflammatory effects of prostaglandin analogs on the ocular surface. Twenty-three rats were divided into four groups. Bimatoprost 0.03% (I), latanoprost 0.005% (II), and travoprost 0.004% (III) were applied during 6 months; a control group (IV) received no
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