检测方案
≥95% (SDS-PAGE)
形式
aqueous glycerol solution
比活
≥1000 U/mg
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CAPN1(823)
应用
人类钙蛋白酶 1 已用在一项研究中评估人类钙蛋白酶 1 和 9 的晶体结构是如何暗示各种作用和自抑制机制的。人钙蛋白酶 1 也已用于研究 N 杂环二肽醛（作为选择性钙蛋白酶抑制剂）的合成、生物学评估和分子模型研究。
生化/生理作用
钙蛋白酶 1 是含有 EF 手基序的中性钙依赖性半胱氨酸蛋白酶。蛋白酶由两个亚基组成；较大的亚基具有四个与木瓜蛋白酶和钙调蛋白同源的结构域。较小的亚基具有一个与钙调蛋白具有同源性的结构域。它被微摩尔水平的钙激活，因此也被称为微钙蛋白酶。它的激活导致细胞蛋白降解、神经元细胞变性和自身免疫性脱髓鞘疾病，例如多发性硬化。
胞质蛋白酶作为上游调节剂参与细胞骨架重塑、自噬和细胞凋亡。
物理属性
钙蛋白酶 1 是异二聚体钙激活的巯基蛋白酶。
单位定义
在25 °C 下，每分钟一个单位水解1皮摩尔的Suc-LLVY-AMC。
外形
在 20 mM 咪唑-HCl，5 mM β-巯基乙醇，1 mM EDTA，1 mM EGTA 和 30％ 甘油中的溶液。
抑制剂
产品编号
说明
价格
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
高风险级别生物产品--人源产品
Tarun Tyagi et al.
Blood, 123(8), 1250-1260 (2013-12-04)
Oxygen-compromised environments, such as high altitude, air travel, and sports, and pathological conditions, such as solid tumors, have been suggested to be prothrombotic. Despite the indispensable role of platelets in thrombus formation, the studies linking hypoxia, platelet reactivity, and thrombus
Nicholas B Woodall et al.
Nature structural & molecular biology, 28(9), 762-770 (2021-09-15)
Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenues for controlling cellular behavior, but
Rebecca M Kandell et al.
ACS nano, 15(12), 20504-20516 (2021-12-07)
Traumatic brain injury (TBI) is a critical public health concern and major contributor to death and long-term disability. After the initial trauma, a sustained secondary injury involving a complex continuum of pathophysiology unfolds, ultimately leading to the destruction of nervous
R Zolfaghari et al.
The Biochemical journal, 241(1), 129-135 (1987-01-01)
A high-Mr neutral endopeptidase-24.5 (NE) that cleaved bradykinin at the Phe5-Ser6 bond was purified to apparent homogeneity from human lung by (NH4)2SO4 fractionation, ion-exchange chromatography and gel filtration. The final enzyme preparation produced a single enzymically active protein band after
M K Squier et al.
Journal of immunology (Baltimore, Md. : 1950), 158(8), 3690-3697 (1997-04-15)
Apoptosis is the common phenotype of programmed or physiologic cell death, the process used to remove excess or defunct cells during normal tissue maintenance. One of the most studied cell types with respect to apoptosis is the immature T cell
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