所有图片(3)
About This Item
经验公式（希尔记法）:
C21H21N·HCl·1.5H2O
CAS号:
分子量:
350.88
EC 号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (TLC)
形式
solid
颜色
white to slightly yellow
溶解性
ethanol: soluble
methanol: soluble
创始人
Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES字符串
Cl.CN1CCC(\CC1)=C2/c3ccccc3C=Cc4ccccc24
InChI
1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2
InChI key
ZEAUHIZSRUAMQG-UHFFFAOYSA-N
基因信息
human ... HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
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应用
盐酸赛庚啶倍半水合物已被用于：
降钙素基因相关肽（CGRP）的抑制
- 检测5-羟色胺受体（5-HT）诱导的炎症中的抗炎活性
- 螃蟹中体内和体外生物检测中5-HT的抑制
- 胚胎生理性实验中5-HT的抑制
降钙素基因相关肽（CGRP）的抑制
生化/生理作用
赛庚啶盐酸盐倍半水合物是一种血清素受体（5-HT2 / 5-HT1C）拮抗剂、H1组胺受体拮抗剂和止痒剂。赛庚啶对5-HT的抑制作用可改善精神分裂症的认知功能。赛庚啶对治疗功能性胃肠道疾病（FGID）有效。食品药品监督管理局（FDA）批准的赛庚啶具有抗抑郁和抗血小板功能。它可有效地治疗血栓栓塞性疾病。赛庚啶能够抑制赖氨酸甲基转移酶7/9（Set7/9），导致乳腺癌细胞中雌激素受体（ERα）的表达减少和生长停滞。
特点和优势
该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Observations on the use of cyproheptadine hydrochloride as an antipruritic agent in allergic cats.
Scott DW, et al.
The Canadian Veterinary Journal. La Revue Veterinaire Canadienne, 39(10), 634-634 (1998)
H W Suh et al.
Neuropeptides, 33(2), 121-129 (2000-02-05)
The present study was designed to investigate the modulatory effects of blockade of spinal histamine receptors on antinociception induced by supraspinally administered mu-epsilon-, delta-, and kappa-opioid receptor agonists. The effects of intrathecal (i.t.) injections with cyproheptadine [a histamine-1 (H1) receptor
Effects of the 5HT antagonist cyproheptadine on neuropsychological function in chronic schizophrenia
Chaudhry IB, et al.
Schizophrenia Research, 53(1-2), 17-24 (2002)
E O Okoro
The Journal of pharmacy and pharmacology, 51(8), 953-957 (1999-09-30)
We have previously shown that elimination of buffer Ca2+ markedly reduced maximum 5-HT-induced contractions. We have now investigated the effect of L-type Ca2+-channel blockers and 5-HT2 receptor antagonists on 5-HT- and K+-induced contractions in rat aorta to explore the possibility
Cyproheptadine: a potentially effective treatment for functional gastrointestinal disorders in children
Krasaelap A and Madani S
Pediatric Annals, 46(3), e120-e125 (2017)
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