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Merck
CN

C6013

胆甾醇半琥珀酸酯 三羟甲基氨基甲烷盐

anionic detergent

别名:

3β-Hydroxy-5-cholestene 3-hemisuccinate, CHEMS, CHS, 胆固醇半琥珀酸酯, 胆甾醇琥珀酸酯

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关于此项目

经验公式(希尔记法):
C31H50O4 · C4H11NO3
化学文摘社编号:
分子量:
607.86
UNSPSC Code:
12352211
eCl@ss:
39023139
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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biological source

synthetic (organic)

Quality Level

assay

≥98% (TLC)

form

powder

functional group

ester

shipped in

ambient

storage temp.

−20°C

SMILES string

NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O

InChI

1S/C31H50O4.C4H11NO3/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5;5-4(1-6,2-7)3-8/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33);6-8H,1-3,5H2/t21-,23+,24+,25-,26+,27+,30+,31-;/m1./s1

InChI key

SLDYONDUXRBLLR-XTCKSVDZSA-N

Application

胆固醇半琥珀酸酯三盐用于:
  • 制备用于葡聚糖合酶测定的溶解缓冲液
  • 制备用于将阿片受体固定在顺磁珠上的免疫沉淀缓冲液。
  • 作为脂质体和蛋白突触结合蛋白1的膜稳定剂
  • 作为叶酸修饰的自微乳化药物递送系统的组成部分。
  • 与正十二烷基 β-D-麦芽糖苷(DDM)一起用于溶解红细胞血影和趋化因子受体CCR1
  • 用于溶解蛋白

Biochem/physiol Actions

胆固醇半琥珀酸盐是一种可电离的阴离子洗涤剂,可稳定大的单层囊泡。这些脂质体囊泡作为抗癌药物、寡核苷酸和抗生素的递送剂。据报道胆固醇琥珀酸酯还具有抗增殖活性,并可以在临床上用作抗肿瘤剂。

Preparation Note

浓度为1 mg/ml的半琥珀酸胆固醇三盐在甲醇中生成澄清、无色的溶液。


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.
Ding, W.X., et al.
International Journal of Pharmaceutics, 300, 37-47 (2005)
Sérgio Simões et al.
Advanced drug delivery reviews, 56(7), 947-965 (2004-04-07)
Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stability and circulation time in the bloodstream, targeting to specific tissues or cells, and facilitation of intracytoplasmic delivery. pH-sensitive liposomes have been developed to mediate the introduction
P Mazur et al.
The Journal of biological chemistry, 271(24), 14604-14609 (1996-06-14)
In the yeast Saccharomyces cerevisiae, the family of RHO genes are implicated in the control of morphogenetic events although the molecular targets of these GTP-binding proteins remain largely unknown. The activity of 1,3-beta-D-glucan synthase, the product of which is essential



全球贸易项目编号

货号GTIN
C6013-5G04061833076064
C6013-25G04061833076057