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生物来源
synthetic (organic)
质量水平
方案
≥98% (TLC)
表单
powder
官能团
ester
运输
ambient
储存温度
−20°C
SMILES字符串
NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O
InChI
1S/C31H50O4.C4H11NO3/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5;5-4(1-6,2-7)3-8/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33);6-8H,1-3,5H2/t21-,23+,24+,25-,26+,27+,30+,31-;/m1./s1
InChI key
SLDYONDUXRBLLR-XTCKSVDZSA-N
应用
胆固醇半琥珀酸酯三盐用于：
- 制备用于葡聚糖合酶测定的溶解缓冲液
- 制备用于将阿片受体固定在顺磁珠上的免疫沉淀缓冲液。
- 作为脂质体和蛋白突触结合蛋白1的膜稳定剂
- 作为叶酸修饰的自微乳化药物递送系统的组成部分。
- 与正十二烷基 β-D-麦芽糖苷（DDM）一起用于溶解红细胞血影和趋化因子受体CCR1
- 用于溶解蛋白
生化/生理作用
胆固醇半琥珀酸盐是一种可电离的阴离子洗涤剂，可稳定大的单层囊泡。这些脂质体囊泡作为抗癌药物、寡核苷酸和抗生素的递送剂。据报道胆固醇琥珀酸酯还具有抗增殖活性，并可以在临床上用作抗肿瘤剂。
制备说明
浓度为1 mg/ml的半琥珀酸胆固醇三盐在甲醇中生成澄清、无色的溶液。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Sérgio Simões et al.
Advanced drug delivery reviews, 56(7), 947-965 (2004-04-07)
Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stability and circulation time in the bloodstream, targeting to specific tissues or cells, and facilitation of intracytoplasmic delivery. pH-sensitive liposomes have been developed to mediate the introduction
Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.
Ding, W.X., et al.
International Journal of Pharmaceutics, 300, 37-47 (2005)
Megan L Grove et al.
PloS one, 8(7), e68095-e68095 (2013-07-23)
Genotyping arrays are a cost effective approach when typing previously-identified genetic polymorphisms in large numbers of samples. One limitation of genotyping arrays with rare variants (e.g., minor allele frequency [MAF] <0.01) is the difficulty that automated clustering algorithms have to
Magdalena Grodecka et al.
Glycoconjugate journal, 29(2-3), 93-105 (2012-01-17)
Duffy antigen/receptor for chemokines (DARC) is a glycosylated seven-transmembrane protein acting as a blood group antigen, a chemokine binding protein and a receptor for Plasmodium vivax malaria parasite. It is present on erythrocytes and endothelial cells of postcapillary venules. The
I M Hafez et al.
Biophysical journal, 79(3), 1438-1446 (2000-09-02)
The pH-dependent fusion properties of large unilamellar vesicles (LUVs) composed of binary mixtures of anionic and cationic lipids have been investigated. It is shown that stable LUVs can be prepared from the ionizable anionic lipid cholesteryl hemisuccinate (CHEMS) and the
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