C5923
(-)-可替宁
≥98% (TLC), crystals, nicotine metabolite
别名:
(S)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮, S(-)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮
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关于此项目
经验公式（希尔记法）:
C10H12N2O
化学文摘社编号:
分子量:
176.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
207-634-9
MDL number:
Beilstein/REAXYS Number:
83099
产品名称
(-)-可替宁, ≥98%
InChI
1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
InChI key
UIKROCXWUNQSPJ-VIFPVBQESA-N
SMILES string
CN1[C@@H](CCC1=O)c2cccnc2
assay
≥98%
form
crystals
bp
250 °C/150 mmHg (lit.)
mp
40-42 °C (lit.)
storage temp.
2-8°C
Quality Level
Gene Information
human ... CYP1A2(1544), CYP2A6(1548)
mouse ... Cyp2a5(13087)
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Biochem/physiol Actions
尼古丁在人体内的主要代谢物。
Application
Cotinine has been used:
- for oxygen-glucose deprivation (OGD) studies to model ischemic stroke
- as a standard to determine serum cotinine measurements using liquid chromatography with tandem mass spectrometry (LC-MS/MS)
- to evaluate the adverse developmental potential of cotinine
- to assess cognitive behavior in mice
General description
Cotinine is an alkaloid extracted from tobacco leaves. It can cross the blood-brain barrier. Cotinine is used to treat Alzheimer′s disease (AD), schizophrenia and post-traumatic stress disorder (PTSD).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome
Pardo M, et al.
The European Journal of Neuroscience, 45(4), 490-498 (2017)
Evaluation of serum cotinine cut-off to distinguish smokers from nonsmokers in the Korean population
Ko K, et al.
Annals of Laboratory Medicine, 36(5), 427-433 (2016)
Nicotine and electronic cigarette (E-Cig) exposure decreases brain glucose utilization in ischemic stroke
Sifat AE, et al.
Journal of Neurochemistry, 147(2), 204-221 (2018)
Long-term cardiovascular reprogramming by short-term perinatal exposure to nicotine's main metabolite cotinine
Bastianini S, et al.
Acta Paediatrica (Oslo, Norway : 1992), 107(4), 638-646 (2018)
Cotinine: beyond that expected, more than a biomarker of tobacco consumption
Echeverria Moran V
Frontiers in Pharmacology, 3, 173-173 (2012)
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