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Merck
CN

C5923

Sigma-Aldrich

(-)-可替宁

≥98% (TLC), crystals, nicotine metabolite

别名:

(S)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮, S(-)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮

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About This Item

经验公式(希尔记法):
C10H12N2O
CAS号:
分子量:
176.22
Beilstein:
83099
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

产品名称

(-)-可替宁, ≥98%

质量水平

方案

≥98%

表单

crystals

沸点

250 °C/150 mmHg (lit.)

mp

40-42 °C (lit.)

储存温度

2-8°C

SMILES字符串

CN1[C@@H](CCC1=O)c2cccnc2

InChI

1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

InChI key

UIKROCXWUNQSPJ-VIFPVBQESA-N

基因信息

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一般描述

Cotinine is an alkaloid extracted from tobacco leaves. It can cross the blood-brain barrier. Cotinine is used to treat Alzheimer′s disease (AD), schizophrenia and post-traumatic stress disorder (PTSD).

应用

Cotinine has been used:
  • for oxygen-glucose deprivation (OGD) studies to model ischemic stroke
  • as a standard to determine serum cotinine measurements using liquid chromatography with tandem mass spectrometry (LC-MS/MS)
  • to evaluate the adverse developmental potential of cotinine
  • to assess cognitive behavior in mice

生化/生理作用

尼古丁在人体内的主要代谢物。

象形图

Exclamation mark

警示用语:

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

230.0 °F - closed cup

闪点(°C)

110 °C - closed cup

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number

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访问文档库

Nicotine and electronic cigarette (E-Cig) exposure decreases brain glucose utilization in ischemic stroke
Sifat AE, et al.
Journal of Neurochemistry, 147(2), 204-221 (2018)
Evaluation of serum cotinine cut-off to distinguish smokers from nonsmokers in the Korean population
Ko K, et al.
Annals of Laboratory Medicine, 36(5), 427-433 (2016)
Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome
Pardo M, et al.
The European Journal of Neuroscience, 45(4), 490-498 (2017)
Long-term cardiovascular reprogramming by short-term perinatal exposure to nicotine's main metabolite cotinine
Bastianini S, et al.
Acta Paediatrica (Oslo, Norway : 1992), 107(4), 638-646 (2018)
Cotinine: beyond that expected, more than a biomarker of tobacco consumption
Echeverria Moran V
Frontiers in Pharmacology, 3, 173-173 (2012)

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