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C5874

Sigma-Aldrich

Cidofovir hydrate

≥98% (HPLC), powder, viral DNA synthesis inhibitor

别名:

(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, (S)-HPMPC; Cidovir, HPMPC, Vistide

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About This Item

经验公式（希尔记法）:
C8H14N3O6P · xH2O
CAS号:
113852-37-2
分子量:
279.19 (anhydrous basis)
MDL编号:
MFCD17215968
UNSPSC代码:
12352200
PubChem化学物质编号:
329775105
NACRES:
NA.77

产品名称

Cidofovir hydrate, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated
protect from light

溶解性

deionized water: ≥5 mg/mL (warmed)

储存温度

room temp

SMILES字符串

O.NC1=NC(=O)N(C[C@@H](CO)OCP(O)(O)=O)C=C1

InChI

1S/C8H14N3O6P.H2O/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16;/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16);1H2/t6-;/m0./s1

InChI key

KLJYJZIIJLYJNN-RGMNGODLSA-N

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生化/生理作用

Selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301,H315

危险分类

Acute Tox. 3 Oral - Skin Irrit. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000403276
0000403275
0000400544
0000390479
0000344686

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solubility of Product C5874 (Cidofovir hydrate)?

    Product C5874 (Cidofovir hydrate) is soluble at 22 mg/mL in water, with warming for 3-5 minutes in a 60°C heat bath.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Joanna Jackowska et al.
Lasers in medical science, 34(7), 1433-1440 (2019-02-15)
Mechanical debulking of laryngeal papillomas is associated with voice disorders due to impairment of the vocal fold's mucosa. Intraepithelial injection of cidofovir reduces damage to the laryngeal structures and thus improves vocal parameters. The aim of our study was to
Beatrice Mercorelli et al.
Antimicrobial agents and chemotherapy, 64(10) (2020-07-22)
Posaconazole (PCZ) is a clinically approved drug used predominantly for prophylaxis and salvage therapy of fungal infections. Here, we report its previously undescribed anti-human cytomegalovirus (HCMV) activity. By using antiviral assays, we demonstrated that PCZ, along with other azolic antifungals
Successful treatment of perianal giant condyloma acuminatum in an immunocompromised host with systemic interleukin 2 and topical cidofovir.
Vinod E Nambudiri et al.
JAMA dermatology, 149(9), 1068-1070 (2013-07-05)
Michel Bossens et al.
International journal of clinical pharmacology and therapeutics, 56(3), 134-141 (2018-01-11)
The primary objective was to evaluate the safety and local tolerance of a topical 2% (w/w) cidofovir gel, applied directly to the cervices of women with high-grade cervical intraepithelial neoplasia (CIN 2+). The secondary objective was to evaluate the pharmacokinetics
Stephen D S McCarthy et al.
PLoS neglected tropical diseases, 10(1), e0004364-e0004364 (2016-01-12)
To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). While a number of candidate drugs have shown limited efficacy in vitro and/or in non-human primate studies, differences in experimental methodologies make it difficult
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