C5857
CA-074 甲基酯
≥99% (TLC)
别名:
(L-3-反式-(丙基氨基甲酰)环氧乙烷-2-甲酰基)-L-异亮氨酰-L-脯氨酸甲酯
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选择尺寸
关于此项目
经验公式（希尔记法）:
C19H31N3O6
化学文摘社编号:
分子量:
397.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352108
MDL number:
产品名称
CA-074 甲基酯, ≥99% (TLC)
InChI
1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11?,12-,13-,14-,15-/m0/s1
SMILES string
CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC
InChI key
XGWSRLSPWIEMLQ-RQLZCWDZSA-N
biological source
synthetic (organic)
assay
≥99% (TLC)
form
solid
storage temp.
−20°C
Quality Level
相关类别
Application
使用CA-074甲酯用作心肌细胞、HeLa细胞和胰腺癌PANC-1细胞中的组织蛋白酶B抑制剂。
Biochem/physiol Actions
CA-074甲酯是CA-074的细胞渗透性类似物。它是组织蛋白酶B尤其胞内型的抑制剂，可通过酯酶作用在细胞内转化为活性CA-074。CA-074甲酯还可抑制组织蛋白酶L。
Features and Benefits
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
The cathepsin B-selective inhibitors CA-074 and CA-074Me inactivate cathepsin L under reducing conditions
Steverding D
Open enzyme inhibition Journal, 4(1), 3493-3500 (2011)
Chee Fan Tan et al.
Cells, 9(5) (2020-05-30)
Studies have shown that the process of extracellular vesicles (EVs) secretion and lysosome status are linked. When the lysosome is under stress, the cells would secrete more EVs to maintain cellular homeostasis. However, the process that governs lysosomal activity and
An intracellular form of cathepsin B contributes to invasiveness in cancer
Szpaderska AM and Frankfater A
Cancer Research, 61(8), 3493-3500 (2001)
Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice
Zhang C, et al.
Chinese Medical Journal (English Edition), 122(20), 2489-2496 (2009)
Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-alpha/ASK1/JNK pathway
Wu QQ, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 308(9), H1143-H1154 (2015)
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