C5851
CGP 35348 水合物
≥97% (NMR), solid
别名:
(3-氨基丙基)(二乙氧基甲基)次膦酸 水合物
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关于此项目
经验公式（希尔记法）:
C8H20NO4P · xH2O
化学文摘社编号:
分子量:
225.22 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
CGP 35348 水合物, ≥97% (NMR), solid
InChI
1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2
SMILES string
O.CCOC(OCC)P(O)(=O)CCCN
InChI key
SRBHGEXMDCJOMS-UHFFFAOYSA-N
assay
≥97% (NMR)
form
solid
storage condition
desiccated
color
white
solubility
H2O: >20 mg/mL
originator
Novartis
storage temp.
−20°C
Quality Level
Application
CGP 35348水合物已用作γ-氨基丁酸-B (GABAB)受体抑制剂：
- 用于研究其对大鼠海马体内源光信号(IOS)的影响
- 通过单独使用或与水杨酸钠联用，研究其对大鼠背皮层听觉反应的影响
- 研究其对肝细胞癌细胞(HCC)的影响
Biochem/physiol Actions
CGP 35348是一种γ-氨基丁酸-B (GABAB)受体拮抗剂。它可穿过血脑屏障，对突触后受体的亲和性比突触前受体更高。
Disclaimer
产品具有吸湿性
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Abigail J Houston et al.
European journal of pharmacology, 674(2-3), 327-331 (2011-12-07)
The effects of subcutaneous (s.c.) administration of the GABA(B) receptor agonist baclofen were investigated on primary drinking in rats. Baclofen (1-4 mg/kg) produced a dose-related reduction in cumulative water intake in 16 h water-deprived rats during the 120 min measurement
GABAB receptor antagonists: from synthesis to therapeutic applications.
H Bittiger et al.
Trends in pharmacological sciences, 14(11), 391-394 (1993-11-01)
Pavel Mareš
Epilepsy research, 92(2-3), 125-133 (2010-09-25)
Epileptic seizures activate not only excitatory but also inhibitory systems what results in an arrest of seizures. Our recent data indicate that GABAergic inhibition plays an important role in this process in cortically elicited seizures. We started to study the
S E Sander et al.
Neuroscience, 162(2), 423-430 (2009-05-12)
The GABA(B) receptor (GABA(B)R) agonist baclofen is known to have a beneficial potency in patients who suffer from dystonia, a neurological syndrome characterized by involuntary co-contractions of opposing muscles. The underlying mechanisms of this movement disorder are still unclear. Previous
Zhiyang Song et al.
Pain, 147(1-3), 241-248 (2009-10-20)
The aim of the present study was to examine the role of the spinal serotonergic system in the pain relieving effect of spinal cord stimulation (SCS) using a rat model of mononeuropathy. Tactile withdrawal thresholds, cold responses and heat withdrawal
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