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生物来源
synthetic (organic)
质量水平
检测方案
≥99% (TLC)
形式
powder
溶解性
methanol: 1 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H]([C@H](C)CC)C(=O)N2CCC[C@H]2C(O)=O
InChI
1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10?,11-,12-,13-,14-/m0/s1
InChI key
ZEZGJKSEBRELAS-NSIINPIOSA-N
应用
CA-074 已被用作组织蛋白酶 B 抑制剂：
- 利用 HeLa 细胞研究其对携带 R642M 和 N714K 的 S 蛋白的假型病毒的影响
- 确定自噬在葡萄糖缺乏（GD）诱导的损伤中的作用
- 研究其暴露于组织蛋白酶 B（CATB）对神经元功能的影响
生化/生理作用
CA-074 是组织蛋白酶 B 的有效和选择性抑制剂。它有助于研究组织蛋白酶 B 在体内的生物学功能。研究表明，CA-074 在还原条件下也能抑制组织蛋白酶 L。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Clément Naudin et al.
PloS one, 6(9), e25577-e25577 (2011-10-08)
Cysteine cathepsins have emerged as new players in inflammatory lung disorders. Their activities are dramatically increased in the sputum of cystic fibrosis (CF) patients, suggesting that they are involved in the pathophysiology of CF. We have characterized the cathepsins in
M Murata et al.
FEBS letters, 280(2), 307-310 (1991-03-25)
A series of new epoxysuccinyl peptides were designed and synthesized to develop a specific inhibitor of cathepsin B. Of these compounds, N-(L-3-trans-ethoxycarbonyloxirane-2-carbonyl)-L-isoleucyl-L-proli ne (compound CA-030) and N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-prol ine (compound CA-074) were the most potent and specific inhibitors of cathepsin B
Kazuya Shirato et al.
Journal of virology, 91(1) (2016-11-01)
Human coronavirus 229E (HCoV-229E), a causative agent of the common cold, enters host cells via two distinct pathways: one is mediated by cell surface proteases, particularly transmembrane protease serine 2 (TMPRSS2), and the other by endosomal cathepsin L. Thus, specific
Masashi Asai et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(10), 3720-3730 (2011-07-13)
γ-Secretase catalyzes the cleavage of the intramembrane region of the Alzheimer amyloid precursor protein (APP), generating p3, amyloid-β peptide (Aβ), and the APP intracellular domain (AICD). Although a γ-secretase inhibitor has been shown to cause an accumulation of the APP
Giuseppe Nicastro et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(30), 10493-10498 (2005-07-16)
The Josephin domain plays an important role in the cellular functions of ataxin-3, the protein responsible for the neurodegenerative Machado-Joseph disease. We have determined the solution structure of Josephin and shown that it belongs to the family of papain-like cysteine
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