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Merck
CN

C5490

Sigma-Aldrich

C75

≥98% (HPLC), powder

别名:

4-亚甲基-2-辛基-5-氧代四氢呋喃-3-羧酸

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About This Item

经验公式(希尔记法):
C14H22O4
分子量:
254.32
MDL编号:
UNSPSC代码:
41121801
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear

储存温度

2-8°C

SMILES字符串

CCCCCCCCC1OC(=O)C(=C)C1C(O)=O

InChI

1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)

InChI key

VCWLZDVWHQVAJU-UHFFFAOYSA-N

应用

C75用于:
  • 作为脂肪酸合酶(FASN)抑制剂,测试其相较于二甲双胍,对FASN的直接抑制作用以及减弱乳腺球形成的能力
  • 作为抑制神经胶质瘤干细胞(GSC)中脂肪酸合成的药理抑制剂
  • 作为FAS 抑制剂 对Chang细胞进行预处理,以抑制脂肪生成并逆转过氧化氢诱导的衰老

生化/生理作用

C75有助于提高电离辐射的抗癌能力。
C75是一种新型、有效的脂肪酸合成酶(FAS)合成抑制剂,可用作研究代谢紊乱和癌症中脂肪酸合成的工具。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b
Wahdan-Alaswad RS, et al.
Hormones & Cancer, 5(6), 374-389 (2014)
Yuta Sakae et al.
Biology open, 9(4) (2020-04-09)
The teleost fish, medaka (Oryzias latipes), employs the XX/XY genetic sex determination system. We show here that the phenotypic sex of medaka is affected by changes in lipid metabolism. Medaka larvae subjected to 5 days of starvation underwent female-to-male sex reversal.
Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence
Kim YM, et al.
Test, 285(38), 29069-29077 (2010)
Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75
Rae C, et al.
Chirality, 29(1), 10-13 (2017)
Song-Hyo Jin et al.
PLoS neglected tropical diseases, 11(6), e0005687-e0005687 (2017-06-22)
Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in

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