C5490
C75
≥98% (HPLC), fatty acid synthase (FAS) inhibitor of, powder
别名:
4-亚甲基-2-辛基-5-氧代四氢呋喃-3-羧酸
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关于此项目
经验公式（希尔记法）:
C14H22O4
化学文摘社编号:
分子量:
254.32
UNSPSC Code:
41121801
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
C75, ≥98% (HPLC), powder
SMILES string
CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
InChI key
VCWLZDVWHQVAJU-UHFFFAOYSA-N
InChI
1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
C75用于：
- 作为脂肪酸合酶（FASN）抑制剂，测试其相较于二甲双胍，对FASN的直接抑制作用以及减弱乳腺球形成的能力
- 作为抑制神经胶质瘤干细胞（GSC）中脂肪酸合成的药理抑制剂
- 作为FAS 抑制剂 对Chang细胞进行预处理，以抑制脂肪生成并逆转过氧化氢诱导的衰老
Biochem/physiol Actions
C75是一种新型、有效的脂肪酸合成酶（FAS）合成抑制剂，可用作研究代谢紊乱和癌症中脂肪酸合成的工具。
C75有助于提高电离辐射的抗癌能力。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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PLoS neglected tropical diseases, 11(6), e0005687-e0005687 (2017-06-22)
Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in
Cheulhee Jung et al.
Analytical and bioanalytical chemistry, 408(30), 8583-8591 (2016-04-02)
There are various ways that priming can occur in nucleic acid amplification reactions. While most reactions rely on a primer to initiate amplification, a mechanism for DNA amplification has been developed in which hairpin sequences at the 3' terminus of
Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75
Rae C, et al.
Chirality, 29(1), 10-13 (2017)
Satoshi Kimura et al.
Nucleic acids research, 45(22), 12974-12986 (2017-10-27)
Post-transcriptional modifications of ribosomal RNAs (rRNAs) are involved in ribosome biogenesis and fine-tuning of translation. 5-Hydroxycytidine (ho5C), a modification of unknown biogenesis and function, is present at position 2501 of Escherichia coli 23S rRNA. We conducted a genome-wide screen in
Asuteka Nagao et al.
Nature structural & molecular biology, 24(9), 778-782 (2017-08-08)
The genetic code is not frozen but still evolving, which can result in the acquisition of 'dialectal' codons that deviate from the universal genetic code. RNA modifications in the anticodon region of tRNAs play a critical role in establishing such
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