C5490
C75
≥98% (HPLC), fatty acid synthase (FAS) inhibitor of, powder
别名:
4-亚甲基-2-辛基-5-氧代四氢呋喃-3-羧酸
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关于此项目
经验公式（希尔记法）:
C14H22O4
化学文摘社编号:
分子量:
254.32
UNSPSC Code:
41121801
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
C75, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
2-8°C
SMILES string
CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
InChI
1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)
InChI key
VCWLZDVWHQVAJU-UHFFFAOYSA-N
Application
C75用于：
- 作为脂肪酸合酶（FASN）抑制剂，测试其相较于二甲双胍，对FASN的直接抑制作用以及减弱乳腺球形成的能力
- 作为抑制神经胶质瘤干细胞（GSC）中脂肪酸合成的药理抑制剂
- 作为FAS 抑制剂 对Chang细胞进行预处理，以抑制脂肪生成并逆转过氧化氢诱导的衰老
Biochem/physiol Actions
C75有助于提高电离辐射的抗癌能力。
C75是一种新型、有效的脂肪酸合成酶（FAS）合成抑制剂，可用作研究代谢紊乱和癌症中脂肪酸合成的工具。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
Discover Bioactive Small Molecules for Lipid Signaling Research
Yuta Sakae et al.
Biology open, 9(4) (2020-04-09)
The teleost fish, medaka (Oryzias latipes), employs the XX/XY genetic sex determination system. We show here that the phenotypic sex of medaka is affected by changes in lipid metabolism. Medaka larvae subjected to 5 days of starvation underwent female-to-male sex reversal.
Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence
Kim YM, et al.
Test, 285(38), 29069-29077 (2010)
Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b
Wahdan-Alaswad RS, et al.
Hormones & Cancer, 5(6), 374-389 (2014)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C5490-5MG | 04061833502198 |
| C5490-25MG | 04061833269985 |