C5174
4′-氯地西泮
≥98% (TLC)
别名:
7-氯-5-（4-氯苯基）-1,3-二氢-1-甲基-2H-1,4-苯二氮卓-2-酮, Ro 5-4864, Ro5-4864
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关于此项目
经验公式（希尔记法）:
C16H12Cl2N2O
化学文摘社编号:
分子量:
319.19
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
685202
InChI
1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
SMILES string
O=C1CN=C(C2=CC=C(Cl)C=C2)C3=CC(Cl)=CC=C3N1C
InChI key
PUMYFTJOWAJIKF-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada; Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
solubility
2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble
Quality Level
Gene Information
rat ... Tspo(24230)
Application
4′-氯地西泮在线粒体功能研究中用作转运蛋白配体。此外，也用于研究其对葡萄糖缺失T98G星形胶质细胞的保护作用。
Biochem/physiol Actions
4'-氯二氮卓酮 (Ro5-4864) 是线粒体转运蛋白 18 kDa (TSPO) 的强效选择性配体，以前称为外周苯二氮卓类受体 (PBR)。Ro5-4864 不与 GABA (A) 受体结合，缺乏典型的苯二氮卓类效应，但在多项研究中发现其具有神经保护作用。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
4?-Chlorodiazepam protects mitochondria in T98G astrocyte cell line from glucose deprivation
Baez E, et al.
Neurotoxicity Research, 32(2), 163-171 (2017)
Federico Da Settimo et al.
Journal of medicinal chemistry, 51(18), 5798-5806 (2008-08-30)
Novel N,N-disubstituted indol-3-ylglyoxylamides (1-56), bearing different combinations of substituents R 1-R 5, were synthesized and evaluated as ligands of the translocator protein (TSPO), the 18 kDa protein representing the minimal functional unit of the "peripheral-type benzodiazepine receptor" (PBR). Most of
Sabrina Taliani et al.
Journal of medicinal chemistry, 50(2), 404-407 (2007-01-19)
Fluorescent ligands for the peripheral-type benzodiazepine receptor (PBR) featuring the 7-nitrobenz-2-oxa-1,3-diazol-4-yl moiety were synthesized, based on N,N-dialkyl-2-phenylindol-3-ylglyoxylamides, a potent, selective class of PBR ligands previously described by us. All the new ligands are moderately to highly potent at the PBR
L Veenman et al.
Current molecular medicine, 12(4), 398-412 (2012-02-22)
The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR). TSPO has
Anna M Barron et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(20), 8891-8897 (2013-05-17)
Ligands of the translocator protein (TSPO) elicit pleiotropic neuroprotective effects that represent emerging treatment strategies for several neurodegenerative conditions. To investigate the potential of TSPO as a therapeutic target for Alzheimer's disease (AD), the current study assessed the effects of
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