C5174
4′-氯地西泮
≥98% (TLC)
别名:
7-氯-5-（4-氯苯基）-1,3-二氢-1-甲基-2H-1,4-苯二氮卓-2-酮, Ro 5-4864, Ro5-4864
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C16H12Cl2N2O
化学文摘社编号:
分子量:
319.19
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
685202
InChI
1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
SMILES string
O=C1CN=C(C2=CC=C(Cl)C=C2)C3=CC(Cl)=CC=C3N1C
InChI key
PUMYFTJOWAJIKF-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada; Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
solubility
2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble
Quality Level
Gene Information
rat ... Tspo(24230)
Application
4′-氯地西泮在线粒体功能研究中用作转运蛋白配体。此外，也用于研究其对葡萄糖缺失T98G星形胶质细胞的保护作用。
Biochem/physiol Actions
4'-氯二氮卓酮 (Ro5-4864) 是线粒体转运蛋白 18 kDa (TSPO) 的强效选择性配体，以前称为外周苯二氮卓类受体 (PBR)。Ro5-4864 不与 GABA (A) 受体结合，缺乏典型的苯二氮卓类效应，但在多项研究中发现其具有神经保护作用。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
4?-Chlorodiazepam protects mitochondria in T98G astrocyte cell line from glucose deprivation
Baez E, et al.
Neurotoxicity Research, 32(2), 163-171 (2017)
A TSPO ligand prevents mitochondrial sterol accumulation and dysfunction during myocardial ischemia-reperfusion in hypercholesterolemic rats
Musman J, et al.
Biochemical Pharmacology, 142, 87-95 (2017)
Guillaume Bouyer et al.
Blood, 118(8), 2305-2312 (2011-07-29)
Plasmodium falciparum relies on anion channels activated in the erythrocyte membrane to ensure the transport of nutrients and waste products necessary for its replication and survival after invasion. The molecular identity of these anion channels, termed "new permeability pathways" is
Irene Marginedas-Freixa et al.
International journal of molecular sciences, 19(10) (2018-10-13)
Two main isoforms of the Translocator Protein (TSPO) have been identified. TSPO1 is ubiquitous and is mainly present at the outer mitochondrial membrane of most eukaryotic cells, whereas, TSPO2 is specific to the erythroid lineage, located at the plasma membrane
L Veenman et al.
Current molecular medicine, 12(4), 398-412 (2012-02-22)
The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR). TSPO has
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持