推荐产品
生物来源
Glycine max (soybean)
质量水平
表单
powder
浓度
~65%
运输
ambient
储存温度
−20°C
SMILES字符串
[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])[C@H](C)CC[C@H](C)C(C)C
InChI
1S/C28H48O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h9,18-20,22-26,29H,7-8,10-17H2,1-6H3/t19-,20+,22-,23-,24+,25-,26-,27-,28+/m0/s1
InChI key
SGNBVLSWZMBQTH-ZRUUVFCLSA-N
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应用
在对植物来源的油样品进行GC 和HPLC 分析时，菜油甾醇被用作标准品。
生化/生理作用
植物甾醇。可降低膳食胆固醇的吸收。
菜油甾醇是一种植物甾醇，主要存在于坚果、水果、豆类和种子中。虽然它是胆固醇的类似物，但它在人体中的吸收很差，并且能够竞争性抑制胆固醇的吸收。菜油甾醇降低了参与肝细胞和肠细胞中胆固醇代谢的基因的转录，并且对心血管疾病的治疗具有积极影响。
质量
通过HPLC和GC分析得到二氢菜子甾醇（24β-甲基-5-胆甾烯-3β-醇；24[S]-麦角甾-5-烯-3β-醇）的含量约为98%，但 13C-NMR显示含量约为35％。
制备说明
菜油甾醇以20mg/ml浓度溶于氯仿，可得到透明、无色至淡黄色的溶液。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hannu Päivä et al.
Clinical pharmacology and therapeutics, 78(1), 60-68 (2005-07-09)
Myopathy, probably caused by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibition in skeletal muscle, rarely occurs in patients taking statins. This study was designed to assess the effect of high-dose statin treatment on cholesterol and ubiquinone metabolism and mitochondrial function in human skeletal
Kang Jiang et al.
Journal of the American Society for Mass Spectrometry, 30(9), 1700-1712 (2019-05-22)
Phytosterols and tocopherols are essential for plant biochemistry, and they possess beneficial health effects for humans. Evaluating the tandem mass spectrometric (MS/MS) behavior of phytosterols and tocopherols is needed for the development of a qualitative and quantitative method for these
Juan P Barrios-Ramos et al.
Journal of the science of food and agriculture, 92(11), 2349-2357 (2012-03-21)
The effect of functional foods alone or in combination (cocoa + soy + oats + fish oil) on hepatic damage in rats affected with metabolic syndrome was investigated. Rats that were given cocoa showed a decrease in the levels of
D Lütjohann et al.
Journal of lipid research, 36(8), 1763-1773 (1995-08-01)
Absorption of dietary cholesterol, campesterol, and sitosterol, cholesterol balance, and fecal excretion of plant sterols were determined in three unrelated patients with phytosterolemia and three healthy volunteers during constant intake of cholesterol and plant sterols using accurate gas-liquid chromatography-mass spectrometry
S H Kasmas et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 45(11), 1095-1101 (2012-07-18)
Effective statin therapy is associated with a marked reduction of cardiovascular events. However, the explanation for full benefits obtained for LDL cholesterol targets by combined lipid-lowering therapy is controversial. Our study compared the effects of two equally effective lipid-lowering strategies
实验方案
Separation of Cholesterol; Brassicasterol; Campesterol; Stigmasterol; β-Sitosterol
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