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生物来源
Xanthium sibiricum
方案
≥98% (HPLC)
表单
solid
旋光性
[α]/D -34 to -48°, c = 0.5 in water
储存条件
desiccated
颜色
white
溶解性
H2O: ≥10 mg/mL
储存温度
−20°C
应用
羧基苍术苷钾盐已被用作Ca 2+诱导的mPTP(1-甲基-4-苯基-1,2,3,6-四氢吡啶) 开环的激活剂 。它还已被用作腺嘌呤核苷酸转运蛋白(ANT)抑制剂，以研究抑制完整T98G神经胶质瘤细胞中的氧化磷酸化的抑制作用。
生化/生理作用
羧基苍术苷是细胞溶质侧特异性线粒体ADP/ATP载体的高选择性抑制剂；即腺嘌呤核苷酸转位酶（ANT）；使ANT的c构象稳定，导致渗透性转换孔（PTP）开放、线粒体膜电位丧失和细胞凋亡。
特点和优势
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Juliana S Ruas et al.
PloS one, 11(3), e0150967-e0150967 (2016-03-08)
The maximal capacity of the mitochondrial electron transport system (ETS) in intact cells is frequently estimated by promoting protonophore-induced maximal oxygen consumption preceded by inhibition of oxidative phosphorylation by oligomycin. In the present study, human glioma (T98G and U-87MG) and
The regulator of calcineurin 1 increases adenine nucleotide translocator 1 and leads to mitochondrial dysfunctions
Jiang H, et al.
Journal of Neurochemistry, 140(2), 307-319 (2017)
Underestimation of the maximal capacity of the mitochondrial electron transport system in oligomycin-treated cells
Ruas J S, et al.
PLoS ONE, 11(3), e0150967-e0150967 (2016)
Lukasz S Borowski et al.
Nucleic acids research, 41(2), 1223-1240 (2012-12-12)
RNA decay is usually mediated by protein complexes and can occur in specific foci such as P-bodies in the cytoplasm of eukaryotes. In human mitochondria nothing is known about the spatial organization of the RNA decay machinery, and the ribonuclease
Chen Zhang et al.
Scientific reports, 7, 44708-44708 (2017-03-21)
Mitochondria are intracellular organelles involved in cell survival and death, and dysfunctions of mitochondria are related to neurodegenerative diseases. As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial
商品
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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