推荐产品
生物来源
microbial
质量水平
描述
suitable for testing specifications (CHO C. growth inhibitor)
表单
solution
浓度
100 mg/mL in DMSO
溶解性
DMSO: soluble
抗生素抗菌谱
fungi
yeast
作用机制
protein synthesis | interferes
储存温度
2-8°C
SMILES字符串
O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
基因信息
human ... FKBP1A(2280) , PIN1(5300)
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特异性
经测试可用于细胞生长停滞、选择抗环己酰亚胺的酵母、诱导凋亡、以及促进通过FasL凋亡的诱导。
生化/生理作用
环己酰亚胺（CHX）是由灰链霉菌产生的一种抗生素。它的主要生物学活性是真核生物中的翻译抑制，从而导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。
其他说明
保存于密闭容器内，置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。储存类别（TRGS 510）：不可燃，急性毒性，1和2类/剧毒有害物质。
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
法规信息
监管及禁止进口产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Hye-Yeoung Yun et al.
PLoS biology, 17(7), e3000367-e3000367 (2019-07-20)
Human papillomaviruses (HPVs) are causative agents of various diseases associated with cellular hyperproliferation, including cervical cancer, one of the most prevalent tumors in women. E7 is one of the two HPV-encoded oncoproteins and directs recruitment and subsequent degradation of tumor-suppressive
Konstantinos Boulias et al.
Molecular cell, 75(3), 631-643 (2019-07-08)
mRNAs are regulated by nucleotide modifications that influence their cellular fate. Two of the most abundant modified nucleotides are N6-methyladenosine (m6A), found within mRNAs, and N6,2'-O-dimethyladenosine (m6Am), which is found at the first transcribed nucleotide. Distinguishing these modifications in mapping
Matthias Rottmann et al.
Science (New York, N.Y.), 329(5996), 1175-1180 (2010-09-04)
Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments. The spirotetrahydro-beta-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium vivax clinical isolates
Xing Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(43), 15438-15443 (2014-10-16)
The receptor-interacting kinase-3 (RIP3) and its downstream substrate mixed lineage kinase domain-like protein (MLKL) have emerged as the key cellular components in programmed necrotic cell death. Receptors for the cytokines of tumor necrosis factor (TNF) family and Toll-like receptors (TLR)
Anna Duarri et al.
Annals of neurology, 72(6), 870-880 (2013-01-03)
To identify the causative gene for the neurodegenerative disorder spinocerebellar ataxia type 19 (SCA19) located on chromosomal region 1p21-q21. Exome sequencing was used to identify the causal mutation in a large SCA19 family. We then screened 230 ataxia families for
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