所有图片(4)
About This Item
经验公式（希尔记法）:
C21H36N7O16P3S · xNa+ · yH2O
CAS号:
分子量:
767.53 (anhydrous free acid basis)
EC 号:
UNSPSC代码:
12352205
PubChem化学物质编号:
NACRES:
NA.75
生物来源
yeast
质量水平
描述
cofactor for acyl transfer
产品线
BioReagent
检测方案
≥85% (HPLC)
形式
powder
技术
cell culture | mammalian: suitable
溶解性
water: 50 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
InChI key
SYTRWOCXZXQBPW-CLVRNSBASA-M
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应用
辅酶 A 钠盐水合物已用于：
- 支链氨基转移酶测定和蛋白质测定
- 吡咯基-S-Bmp1（酰基载体蛋白（ACP）-硫酯酶（TE）二结构域蛋白）被 Bmp2 卤化的测定中
- 作为细胞外辅酶 A（CoA），在体外和体内实验中研究细胞和生物体获得 CoA 的替代途径
生化/生理作用
辅酶 A（CoA）是一种普遍存在的辅因子，在许多代谢途径中发挥着重要作用，主要是作为酰基辅酶 A。它对三羧酸循环以及脂肪酸的合成和氧化至关重要。辅酶 A 促进酰基转移，特别是在脂肪酸和脂质代谢反应中的酰基转移。它与神经退行性变、自噬、蛋白质乙酰化和信号传导有关。
质量
使用磷酸转乙酰酶酶促测定。约 95％ CoA-SH
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Balaji Srinivasan et al.
Nature chemical biology, 11(10), 784-792 (2015-09-01)
The metabolic cofactor coenzyme A (CoA) gained renewed attention because of its roles in neurodegeneration, protein acetylation, autophagy and signal transduction. The long-standing dogma is that eukaryotic cells obtain CoA exclusively via the uptake of extracellular precursors, especially vitamin B5
Yongzhong Wei et al.
World journal of gastroenterology, 14(2), 193-199 (2008-01-12)
Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD
Yao Rong et al.
eLife, 10 (2021-08-20)
TMEM120A, a member of the transmembrane protein 120 (TMEM120) family, has a pivotal function in adipocyte differentiation and metabolism, and may also contribute to sensing mechanical pain by functioning as an ion channel named TACAN. Here we report that expression
Krista Yang et al.
STAR protocols, 2(3), 100687-100687 (2021-08-18)
Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria freshly isolated from tissue, along with examples to assess the potency and specificity
Le Tran Phuc Khoa et al.
Cell stem cell, 27(3), 441-458 (2020-07-02)
Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process
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