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质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: ~30 mg/mL
创始人
Johnson & Johnson
SMILES字符串
O.CO[C@@H]1CN(CCCOc2ccc(F)cc2)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC
InChI
1S/C23H29ClFN3O4.H2O/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16;/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29);1H2/t20-,22+;/m0./s1
InChI key
QBYYXIDJOFZORM-IKGOIYPNSA-N
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生化/生理作用
5-HT 4 血清素受体激动剂。
特点和优势
该化合物由 Johnson & Johnson 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Mihai Covasa et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 285(3), R641-R648 (2003-05-31)
MK-801, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, enhances gastric emptying while increasing food intake. Although our previously reported results implicate the vagus in MK-801's effect on feeding, it is not clear whether vagal motor fibers participate in the feeding response.
Atsuko Inui et al.
Japanese journal of pharmacology, 90(4), 313-320 (2002-12-26)
It is known that 5-HT(4) receptors in the colon of guinea pigs show a distribution similar to that in humans. Thus, we examined the effects of mosapride citrate (mosapride) and cisapride, two 5-HT(4)-receptor agonists, on colonic motility in conscious guinea
M R Briejer et al.
The Journal of pharmacology and experimental therapeutics, 274(2), 641-648 (1995-08-01)
In the guinea pig proximal colon, 5-hydroxytryptamine (5-HT) stimulates neuronal 5-HT1-like receptors to induce relaxations that are mediated by nitric oxide and ATP. In the current study, the effects of cisapride and structural analogs on these 5-HT-induced relaxations were investigated.
Haruka Nishimuta et al.
The AAPS journal, 21(2), 20-20 (2019-01-24)
Accurate prediction of human pharmacokinetics for drugs remains challenging, especially for non-cytochrome P450 (P450) substrates. Hepatocytes might be suitable for predicting hepatic intrinsic clearance (CLint) of new chemical entities, because they can be applied to various compounds regardless of the
Henry C Liu et al.
The Journal of pharmacology and experimental therapeutics, 359(1), 215-229 (2016-08-05)
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 "drug" transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of machine-learning methods
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