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应用
消胆胺树脂可用于：
- 作为膳食补充剂，研究小鼠胆汁酸池大小和粪便胆汁酸排出量
- 改变胆汁酸(BA)水平，研究其对野生型(WT)、成纤维生长因子15(Fgf15)−/−和Fgf15转基因(TG)小鼠肝纤维化发展的影响
- 参与体外消化过程，研究其结合胆汁酸(BA)的能力
消胆胺树脂用于蛋白质层析、离子交换层析和阴离子交换介质。考来烯胺已被用于研究缓解胆囊切除术后腹泻、管理顽固性胆汁淤积性瘙痒和肥胖。
生化/生理作用
消胆胺是一种阳离子交换树脂。这种树脂可作为胆汁酸螯合剂，所含氯离子与小肠腔胆汁酸交换后，螯合的胆汁酸从粪便排出，使血清胆汁酸水平下降。消胆胺也用于治疗原发性高胆固醇血症。这种树脂可使低密度脂(LDL)胆固醇剂量依赖性减少。降低冠心病风险。
其他说明
交联聚苯乙烯上的季铵盐官能团
法律信息
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Ellin Simon et al.
Journal of anxiety disorders, 26(2), 287-296 (2012-01-17)
In this study, the cost-effectiveness of three indicated anxiety prevention strategies was examined from a societal perspective. Children (aged 8-12) were recruited via primary schools, selecting children scoring as high-anxious on an anxiety screening questionnaire. Participating children and their parents
Yoshimine Fujii et al.
International journal of pharmaceutics, 421(2), 244-251 (2011-10-18)
A clinical trial of (2S)-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphtyl) propanoic acid (DX-9065) revealed that its oral bioavailability was only 3% when it was administered as a conventional capsule formulation. The low bioavailability of DX-9065 was likely caused by both its poor membrane permeability and
Akiko Ozaki et al.
Sleep medicine, 13(2), 200-206 (2011-12-06)
To assess the quality of life of patients with narcolepsy with cataplexy (NA-CA), narcolepsy without cataplexy (NA w/o CA), and idiopathic hypersomnia without long sleep time (IHS w/o LST) who were taking psychostimulant medication, and to ascertain which factors (including
Shahram Ala et al.
World journal of surgery, 37(3), 657-662 (2012-12-12)
The aim of the present study was to evaluate the efficacy of cholestyramine ointment (15 %) in reducing postoperative pain at rest and during defecation after open hemorrhoidectomy. A total of 91 patients with third and fourth degree hemorrhoids undergoing
Ju-Ling Liu et al.
PLoS genetics, 8(3), e1002553-e1002553 (2012-03-23)
Mammalian bile acids (BAs) are oxidized metabolites of cholesterol whose amphiphilic properties serve in lipid and cholesterol uptake. BAs also act as hormone-like substances that regulate metabolism. The Caenorhabditis elegans clk-1 mutants sustain elevated mitochondrial oxidative stress and display a
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