应用
消胆胺树脂可用于：
- 作为膳食补充剂，研究小鼠胆汁酸池大小和粪便胆汁酸排出量
- 改变胆汁酸(BA)水平，研究其对野生型(WT)、成纤维生长因子15(Fgf15)−/−和Fgf15转基因(TG)小鼠肝纤维化发展的影响
- 参与体外消化过程，研究其结合胆汁酸(BA)的能力
消胆胺树脂用于蛋白质层析、离子交换层析和阴离子交换介质。考来烯胺已被用于研究缓解胆囊切除术后腹泻、管理顽固性胆汁淤积性瘙痒和肥胖。
生化/生理作用
消胆胺是一种阳离子交换树脂。这种树脂可作为胆汁酸螯合剂，所含氯离子与小肠腔胆汁酸交换后，螯合的胆汁酸从粪便排出，使血清胆汁酸水平下降。消胆胺也用于治疗原发性高胆固醇血症。这种树脂可使低密度脂(LDL)胆固醇剂量依赖性减少。降低冠心病风险。
其他说明
交联聚苯乙烯上的季铵盐官能团
法律信息
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Guodong Li et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(11), G829-G837 (2013-10-05)
Farnesoid X receptor (FXR, Nr1h4) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. FXR is essential in maintaining bile acid (BA) homeostasis, and FXR(-/-) mice develop cholestasis, inflammation, and spontaneous liver tumors. The signal transducer and activator
Guillermo Rodríguez-Gutiérrez et al.
Journal of agricultural and food chemistry, 62(36), 8973-8981 (2014-08-21)
A process based on a steam explosion pretreatment and alkali solution post-treatment was applied to fractionate olive stones (whole and fragmented, without seeds) and olive cake into their main constitutive polymers of cellulose (C), hemicelluloses (H), and lignin (L) under
Robert W Crawford et al.
PLoS pathogens, 8(9), e1002918-e1002918 (2012-10-03)
Intestinal inflammation changes the luminal habitat for microbes through mechanisms that have not been fully resolved. We noticed that the FepE regulator of very long O-antigen chain assembly in the enteric pathogen Salmonella enterica serotype Typhimurium (S. Typhimurium) conferred a
A R Bolier et al.
Acta gastro-enterologica Belgica, 75(4), 399-404 (2013-02-14)
Pruritus can be the dominant symptom of cholestatic liver disease but is difficult to treat since unraveling its pathophysiology is a great challenge. Serum autotaxin activity correlates with pruritus intensity, but its causal relationship, expression pattern and exact mode of
Ju-Ling Liu et al.
PLoS genetics, 8(3), e1002553-e1002553 (2012-03-23)
Mammalian bile acids (BAs) are oxidized metabolites of cholesterol whose amphiphilic properties serve in lipid and cholesterol uptake. BAs also act as hormone-like substances that regulate metabolism. The Caenorhabditis elegans clk-1 mutants sustain elevated mitochondrial oxidative stress and display a
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