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生物来源
synthetic (organic)
质量水平
无菌性
non-sterile
产品线
BioReagent
形式
powder
分子量
~1320 g/mol
标记范围
1.5-2.1 methyl per mol glucose
技术
cell culture | mammalian: suitable
mp
180-182 °C (lit.)
溶解性
H2O: 50 mg/mL
储存温度
room temp
InChI
1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3
InChI key
QGKBSGBYSPTPKJ-UHFFFAOYSA-N
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一般描述
天然环糊精的溶解度非常低。在20世纪60年代后期，人们发现2、3和6羟基位置的化学取代能大大增加溶解度。大多数化学改性环糊精能够在水中达到50% (w/v)的浓度。
应用
- 研究精子膜上的胆固醇消耗对精子顶体反应能力的影响。
- 确定小窝蛋白过表达的作用及其丧失对生存和促生长信号传导的影响
- 传统体外受精
生化/生理作用
重悬
WGK
WGK 3
闪点(°F)
368.6 °F
闪点(°C)
187 °C
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
What is the molecular weight of Methyl-β-cyclodextrin, Product No. C4555?
The approximate molecular weight is 1320 g/mol. The molecular weight can vary from lot to lot due to variation in the methyl content of the product. The molecular weight of this product is dependent on the average number of methyl groups per glucose residue (reported on the lot specific Certificate of Analysis). View the specification sheet above.
How can I make a solution of Methyl-β-cyclodextrin, Product C4555?
This product is tested and found soluble at 50 mg/ml in 1 M NaOH yielding a clear, colorless solution. This product is also soluble in water (150 mg/ml), yielding a clear, colorless solution. Aqueous solutions may be obtained by stirring 30 minutes at room temperature. Alternatively, sonication with cooling may be employed.
How should a solution of Methyl-β-cyclodextrin, Product C4555, be sterilized?
Solutions can be sterile filtered using a 0.2 μm membrane. We do not recommend autoclaving the solution. The product as supplied is not sterile.
How does Methyl-β-cyclodextrin, Product C4555, work to solubilize products that have minimal solubility in aqueous solutions for use in cell culture?
The cavity diameter of β -cyclodextrins compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. Hydrophobic molecules are incorporated into the cavity of cyclodextrins by displacing water. This reaction is favored by the repulsion of the molecule by water. This effectively encapsulates the molecule of interest within the cyclodextrin, rendering the molecule water soluble. When the water soluble complex is diluted in a much larger volume of aqueous solvent, the process is reversed, thereby releasing the molecule of interest into the solution.
What concentration of Methyl-β-cyclodextrin, Product C4555, do I use to remove cholesterol from cell membranes?
This product has been used to reduce the cholesterol content of cell membranes at 10 - 50 mM.References:Eur J Cell Biol. 1999 Jul, 78(7): 473-84.Lipids. 1996 Aug, 31(8): 817-28.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is Product C4555, Methyl-β-cyclodextrin?
Methyl-β-cyclodextrin is used as a "carrier" molecule to facilitate the dissolution of compounds with low solubility in water.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
商品
How palmitic acid, other fatty acids and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.
棕榈酸等脂肪酸和其他细胞培养成分如何影响无血清、无蛋白细胞培养系统（用于生物制造包括单克隆抗体在内的异源蛋白）的性能。
Cyclodextrin solubilizes fat-soluble vitamins and hormones, enhancing their solubility in water for cell culture applications.
How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.
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