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Merck
CN

C4493

葫芦素 I

≥95% (HPLC), solid

别名:

2,16α,20,25-四羟基-9-甲基-19-去甲-9β,10α-羊毛甾-1,5,23-三烯-3,11,22-三酮, JSI-124, NSC 521777, 喷瓜苦素 B

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关于此项目

经验公式（希尔记法）:
C30H42O7 · xH2O
化学文摘社编号:
2222-07-3
分子量:
514.65 (anhydrous basis)
EC 号:
218-736-8
MDL编号:
MFCD09971044
UNSPSC代码:
12352200
PubChem化学物质编号:
329775065
NACRES:
NA.77

主要文件

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质量水平

100

方案

≥95% (HPLC)

表单

solid

颜色

white to off-white

溶解性

DMSO: >5 mg/mL

储存温度

−20°C

SMILES字符串

O.CC(C)(O)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C

InChI

1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6;/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3;1H2/b12-11+;/t17-,19-,20+,23+,27+,28-,29+,30+;/m1./s1

InChI key

ZKDSPEWKSJCXQE-NEBRQAMTSA-N

相关类别

生化/生理作用

葫芦素 I (JSI-124) 是一种新型的 JAK 激酶 2/信号转导子和转录激活子 3 (JAK2/STAT3) 信号通路选择性抑制剂，具有抗增殖和抗肿瘤属性。
葫芦素 I 是一种新型选择性 JAK/STAT3 抑制剂。

特点和优势

该化合物是受体分类及信号转导手册上JAK页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

危险分类

Acute Tox. 1 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000188982
0000128524
0000163953
0000163953
0000128524

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Ommoleila Molavi et al.
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Constitutively activated signal transducer and activator of transcription-3 (STAT3) in tumor and dendritic cells (DCs) plays a critical role in tumor-induced immunosuppression. This is considered a major challenge in effective immunotherapy of cancer. Herein we describe the development of a
Trisha R Stankiewicz et al.
The Journal of biological chemistry, 287(20), 16835-16848 (2012-03-02)
In several neuronal cell types, the small GTPase Rac is essential for survival. We have shown previously that the Rho family GTPase inhibitor Clostridium difficile toxin B (ToxB) induces apoptosis in primary rat cerebellar granule neurons (CGNs) principally via inhibition
Patrick Innamarato et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 28(10), 2252-2270 (2020-07-03)
Adoptive T cell therapy (ACT) in combination with lymphodepleting chemotherapy is an effective strategy to induce the eradication of tumors, providing long-term regression in cancer patients. Despite that lymphodepleting regimens condition the host for optimal engraftment and expansion of adoptively transferred
Abdullah Mahmud et al.
Biomacromolecules, 10(3), 471-478 (2009-01-30)
An increase in the degree of chemical compatibility between drug and polymeric structure in the core has been shown to raise the encapsulation efficiency and lower the rate of drug release from polymeric micelles. In this study, to achieve an
Yi-Wei Chen et al.
Molecular cancer therapeutics, 9(11), 2879-2892 (2010-11-11)
Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer worldwide. Signal transducers and activators of transcription 3 (STAT3) signaling is reported to promote tumor malignancy and recurrence in HNSCC. Cucurbitacins, triterpenoid derivatives, are strong STAT3 inhibitors with anticancer
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