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C4493

Sigma-Aldrich

葫芦素 I

≥95% (HPLC), solid

别名:

2,16α,20,25-四羟基-9-甲基-19-去甲-9β,10α-羊毛甾-1,5,23-三烯-3,11,22-三酮, JSI-124, NSC 521777, 喷瓜苦素 B

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About This Item

经验公式（希尔记法）:
C30H42O7 · xH2O
CAS号:
2222-07-3
分子量:
514.65 (anhydrous basis)
EC 号:
218-736-8
MDL编号:
MFCD09971044
UNSPSC代码:
12352200
PubChem化学物质编号:
329775065
NACRES:
NA.77

质量水平

100

方案

≥95% (HPLC)

表单

solid

颜色

white to off-white

溶解性

DMSO: >5 mg/mL

储存温度

−20°C

SMILES字符串

O.CC(C)(O)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C

InChI

1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6;/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3;1H2/b12-11+;/t17-,19-,20+,23+,27+,28-,29+,30+;/m1./s1

InChI key

ZKDSPEWKSJCXQE-NEBRQAMTSA-N

生化/生理作用

葫芦素 I (JSI-124) 是一种新型的 JAK 激酶 2/信号转导子和转录激活子 3 (JAK2/STAT3) 信号通路选择性抑制剂，具有抗增殖和抗肿瘤属性。
葫芦素 I 是一种新型选择性 JAK/STAT3 抑制剂。

特点和优势

该化合物是受体分类及信号转导手册上JAK页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

危险分类

Acute Tox. 1 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000188982
0000128524
0000163953
0000163953
0000128524

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