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Merck
CN
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主要文件

安全信息

C4461

Sigma-Aldrich

硫酸粘杆菌素 硫酸盐

≥19,000 IU/mg

别名:

多粘菌素E

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About This Item

CAS号:
1264-72-8
EC 号:
215-034-3
MDL编号:
MFCD00146495
UNSPSC代码:
51102829
eCl@ss:
34050906
NACRES:
NA.85

表单

powder

质量水平

200

比活

≥19,000 IU/mg

抗生素抗菌谱

Gram-negative bacteria

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES字符串

[S](=O)(=O)(O)O.N1[C@H](C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C1=O)CCN)CCN)CC(C)C)CC(C)C)CCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCC(CC)C)CCN)[C@H](O)C)CCN)[C@H](O)C

InChI

1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1

InChI key

ZJIWRHLZXQPFAD-LRYSGCCDSA-N

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一般描述

化学结构：肽

应用

硫酸粘杆菌素被用于透化细菌细胞膜以及研究甘露糖抗性血凝和某些生物体(如鲍曼不动杆菌 A. baumannii )的抗生素耐药性。 它已被用于研究大鼠肾脏hephrotoxicity毒性 ，以及对铜绿假单胞菌的MIC值、时间杀灭动力学和抗生素后效应（PAE） 。

生化/生理作用

作用机制：与革兰氏阴性菌细胞质膜上的脂质结合并破坏细胞壁完整性。
抗菌谱： 革兰氏阴性菌。
作用机制：与革兰氏阴性菌细胞质膜上的脂质结合并破坏细胞壁完整性。
抗菌谱： 革兰氏阴性菌。硫酸粘杆菌素的肾重吸收被认为可能涉及到有机阳离子转运蛋白和肽转运蛋白，并且该过程对pH敏感 。

分析说明

易溶于水，几乎不溶于丙酮和乙醇（96％）

其他说明

保持容器密闭，置于干燥通风处。

相关产品

产品编号
说明
价格

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P301 + P330 + P331 + P310

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000380014
0000380016
0000360496
0000360497
0000360499

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Peng Cui et al.
Antimicrobial agents and chemotherapy, 60(11), 6867-6871 (2016-09-08)
Persisters are small populations of quiescent bacterial cells that survive exposure to bactericidal antibiotics and are responsible for many persistent infections and posttreatment relapses. However, little is known about how to effectively kill persister bacteria. In the work presented here
Lisa M Leung et al.
Journal of clinical microbiology, 57(3) (2018-12-21)
Acinetobacter baumannii is a prevalent nosocomial pathogen with a high incidence of multidrug resistance. Treatment of infections due to this organism with colistin, a last-resort antibiotic of the polymyxin class, can result in the emergence of colistin-resistant strains. Colistin resistance
Deepesh Nagarajan et al.
Science advances, 5(7), eaax1946-eaax1946 (2019-07-30)
Drug resistance is a public health concern that threatens to undermine decades of medical progress. ESKAPE pathogens cause most nosocomial infections, and are frequently resistant to carbapenem antibiotics, usually leaving tigecycline and colistin as the last treatment options. However, increasing
Mehri Haeili et al.
Microbial drug resistance (Larchmont, N.Y.), 24(9), 1271-1276 (2018-03-29)
Colistin is considered a last-hope antibiotic against extensively drug-resistant isolates of Acinetobacter baumannii. Resistance to colistin has been rarely reported for A. baumannii. Genetic alterations in the PmrA-PmrB two-component system and lipid A biosynthesis genes may be associated with colistin
Candace M Marr et al.
Frontiers in microbiology, 11, 595798-595798 (2020-11-17)
Acinetobacter baumannii is a problematic pathogen due to its common expression of extensive drug resistance (XDR) and ability to survive in the healthcare environment. These characteristics are mediated, in part, by the signal transduction system BfmR/BfmS. We previously demonstrated, in
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