所有图片(1)
About This Item
经验公式（希尔记法）:
C25H26N9NaO8S2
CAS号:
分子量:
667.65
Beilstein:
4902135
EC 号:
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.85
推荐产品
质量水平
方案
870-1015 μg/mg (anhydrous basis)
表单
powder or crystals
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
cell wall synthesis | interferes
储存温度
2-8°C
SMILES字符串
[Na+].CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSc4nnnn4C)=C(N3C2=O)C([O-])=O)c5ccc(O)cc5)C(=O)C1=O
InChI
1S/C25H27N9O8S2.Na/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);/q;+1/p-1/t15-,16-,22-;/m1./s1
InChI key
NCFTXMQPRQZFMZ-WERGMSTESA-M
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一般描述
Chemical structure: ß-lactam
应用
Cefoperazone is used to study drug-protein binding, expression and inhibition of penicillin-binding proteins (PBPs) during cell wall synthesis.
生化/生理作用
Cefoperazone exerts its bactericidal effect by inhibiting the mucopeptide synthesis that affects the structure of bacterial cell wall. It has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney.
其他说明
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A Meulemans
Antimicrobial agents and chemotherapy, 36(2), 295-298 (1992-02-01)
The apparent diffusion coefficient of a bound drug, cefoperazone, was studied. The protein binding of cefoperazone was studied by voltammetry, a technique which permitted instant measurements. The apparent diffusion coefficients were similar in agar and fibrin and lower in rat
B Gonik et al.
Antimicrobial agents and chemotherapy, 30(6), 874-876 (1986-12-01)
Limited pharmacokinetic data for cefoperazone are available from the parturient. Because cefoperazone has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney, pregnancy-induced physiologic alterations can influence its deposition and clearance. Twelve term parturients receiving
Christopher Staley et al.
Microbiome, 5(1), 87-87 (2017-08-02)
Human microbiota-associated (HMA) animal models relying on germ-free recipient mice are being used to study the relationship between intestinal microbiota and human disease. However, transfer of microbiota into germ-free animals also triggers global developmental changes in the recipient intestine, which
Katie L Mason et al.
Infection and immunity, 80(1), 150-158 (2011-10-12)
The indigenous bacterial microbiome of the stomach, including lactobacilli, is vital in promoting colonization resistance against Candida albicans. However, there are gaps in our understanding about C. albicans gastric colonization versus disease, especially during the postantibiotic recovery phase. This study
M Ugarte-Ruiz et al.
Journal of applied microbiology, 113(1), 200-208 (2012-04-27)
To identify the optimal method for detection of thermophilic Campylobacter at various stages in the food chain, three culture-dependent (direct plating, Bolton and Preston enrichment) and one molecular method (qPCR) were compared for three matrices: poultry faeces (n = 38), neck skin
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