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About This Item
经验公式（希尔记法）:
C21H36N7O16P3S · xH2O
CAS号:
分子量:
767.53 (anhydrous basis)
Beilstein:
77809
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.21
推荐产品
生物来源
yeast
质量水平
方案
≥85% (UV, HPLC)
表单
powder
官能团
phospholipid
运输
ambient
储存温度
−70°C
SMILES字符串
O.CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n2cnc3c(N)ncnc23)[C@@H](O)C(=O)NCCC(=O)NCCS
InChI
1S/C21H36N7O16P3S.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);1H2/t11-,14-,15-,16+,20-;/m1./s1
InChI key
TVSAELAFGDOPKI-BLPRJPCASA-N
应用
辅酶A水合物已用于中华绒螯蟹体内重组乙酰乙酰辅酶A硫解酶（rACAT）的硫解酶测定。它可以用作拉曼光谱测定中的参考标准品。
生化/生理作用
辅酶A（CoA）是由半胱氨酸、泛酸和ATP合成的必需代谢辅助因子。
辅酶A（CoA）是由半胱氨酸、泛酸和ATP合成的必需代谢辅助因子。CoA在许多代谢途径中起重要作用，包括三羧酸循环，以及脂肪酸的合成和氧化。CoA的主要功能之一是酰基的携带和转移。酰化衍生物，例如乙酰-CoA，是许多代谢反应中的关键中间体。在饥饿期间以及癌症、糖尿病和酗酒等条件下，CoA水平可能会发生变化。
注意
游离酸不如钠盐或锂盐稳定；在−80 °C下储存时，6个月内会发生5％的分解。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Gregory R Wagner et al.
The Journal of biological chemistry, 288(40), 29036-29045 (2013-08-16)
Alterations in mitochondrial protein acetylation are implicated in the pathophysiology of diabetes, the metabolic syndrome, mitochondrial disorders, and cancer. However, a viable mechanism responsible for the widespread acetylation in mitochondria remains unknown. Here, we demonstrate that the physiologic pH and
Rajesh K Harijan et al.
The Biochemical journal, 455(1), 119-130 (2013-08-06)
Thiolases are essential CoA-dependent enzymes in lipid metabolism. In the present study we report the crystal structures of trypanosomal and leishmanial SCP2 (sterol carrier protein, type-2)-thiolases. Trypanosomatidae cause various widespread devastating (sub)-tropical diseases, for which adequate treatment is lacking. The
Ulrike Demmer et al.
The Journal of biological chemistry, 288(9), 6363-6370 (2013-01-18)
Autotrophic members of the Sulfolobales (crenarchaeota) use the 3-hydroxypropionate/4-hydroxybutyrate cycle to assimilate CO2 into cell material. The product of the initial acetyl-CoA carboxylation with CO2, malonyl-CoA, is further reduced to malonic semialdehyde by an NADPH-dependent malonyl-CoA reductase (MCR); the enzyme
Haruyuki Atomi et al.
Biochemical Society transactions, 41(1), 427-431 (2013-01-30)
CoA is a ubiquitous molecule in all three domains of life and is involved in various metabolic pathways. The enzymes and reactions involved in CoA biosynthesis in eukaryotes and bacteria have been identified. By contrast, the proteins/genes involved in CoA
John C Newman et al.
The Journal of biological chemistry, 287(51), 42436-42443 (2012-10-23)
The sirtuins are a family of NAD(+)-dependent protein deacetylases that regulate cell survival, metabolism, and longevity. Three sirtuins, SIRT3-5, localize to mitochondria. Expression of SIRT3 is selectively activated during fasting and calorie restriction. SIRT3 regulates the acetylation level and enzymatic
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