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Merck
CN

C4018

Sigma-Aldrich

胆酰甘氨酸水解酶 来源于产气荚膜梭菌(韦氏梭菌)

lyophilized powder, ≥100 units/mg protein

别名:

3α,7α,12α-三羟基-5β-氯烷-24-甲酰甘氨酸酰胺水解酶

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About This Item

CAS号:
MDL编号:
UNSPSC代码:
12352204
NACRES:
NA.54

表单

lyophilized powder

质量水平

比活

≥100 units/mg protein

组成

Protein, ≥50% biuret

运输

wet ice

储存温度

−20°C

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应用

来自 Sigma 的酶已在各种研究中用于胆汁样品的分析。

生化/生理作用

该酶是一种 N-末端亲核 (Ntn) 水解酶,催化酰胺键水解,从类固醇核心释放甘氨酸/牛磺酸部分,最终生成非结合胆汁酸。已证明可氧化巯基的药物(例如,对汞苯甲酸盐、碘乙酰胺、Hg 2 + 、Cu 2 + 和 Cd 2 + )可强烈抑制 产气荚膜梭菌的胆盐水解酶 (BSH) 活性

单位定义

一个单元将在37°C、pH 5.6 条件下5 min 内将 1.0μmol 甘胆酸水解为甘氨酸和胆酸。

外形

部分纯化的冻干粉末,含有缓冲盐和稳定剂

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Resp. Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Effects of Quercetin and Rutin on Serum and Hepatic Lipid Concentrations, Fecal Steroid Excretion and Serum Antioxidant Properties
Nakamura Y, et al.
Journal of Health Science, 46(4), 229-240 (2000)
Bile salt hydrolase activity in probiotics.
Máire Begley et al.
Applied and environmental microbiology, 72(3), 1729-1738 (2006-03-07)
Maksim Rossocha et al.
Biochemistry, 44(15), 5739-5748 (2005-04-13)
Bacterial bile salt hydrolases catalyze the degradation of conjugated bile acids in the mammalian gut. The crystal structures of conjugated bile acid hydrolase (CBAH) from Clostridium perfringens as apoenzyme and in complex with taurodeoxycholate that was hydrolyzed to the reaction
Konstantinos C Mountzouris et al.
Clinical nutrition (Edinburgh, Scotland), 28(3), 318-324 (2009-02-19)
Little is known about fasting effects on gut bacterial metabolism. As probiotics are purported to be beneficial for health, this study aimed to investigate the response of gut microbial metabolism on fasting with or without probiotic administration. Sixty male adult
F Kannenberg et al.
The Journal of biological chemistry, 274(50), 35455-35460 (1999-12-10)
Peroxisomal beta-oxidation plays an important role in the metabolism of a wide range of substrates, including various fatty acids and the steroid side chain in bile acid synthesis. Two distinct thiolases have been implicated to function in peroxisomal beta-oxidation: the

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