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Merck
CN

C3865

抗钙粘附蛋白抗体，小鼠单克隆抗体 小鼠抗

clone GC-4, purified from hybridoma cell culture

别名:

抗 A 细胞粘附分子, 抗 A-CAM

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00164511
Conjugate:
unconjugated
Clone:
GC-4, monoclonal
Application:
electron microscopy
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Species reactivity:
chicken, monkey, mouse, human, rabbit, rat
Citations:
110
Technique(s):
electron microscopy: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections
western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts
Uniprot accession no.:
P19022

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产品名称

抗钙粘附蛋白抗体，小鼠单克隆抗体 小鼠抗, clone GC-4, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

GC-4, monoclonal

form

buffered aqueous solution

mol wt

antigen 135 kDa

species reactivity

chicken, monkey, mouse, human, rabbit, rat

technique(s)

electron microscopy: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections
western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts

isotype

IgG1

UniProt accession no.

P19022

application(s)

research pathology

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)

相关类别

Physical form

在pH7.4的0.01M磷酸盐缓冲盐水中，用0.2μl过滤的溶液。

General description

N-钙粘着蛋白是钙粘着蛋白家族的成员，其以钙依赖性方式介导细胞粘着。N-钙粘着蛋白是一种跨膜糖蛋白，位于质膜的细胞粘着连接处。现已确知该蛋白质位于细胞膜中。

Other Notes

克隆 GC-4 也称为 GB-9。

Application

Anti-N-Cadherin 抗体适用于以下程序：
  • 电子显微镜术
  • 流式细胞术
  • 免疫细胞化学
  • 免疫组化，浓度为 10-20μ g/mL，使用大鼠心肌冷冻切片
  • 免疫印迹，浓度为 10-20μg/mL，使用鸡心肌或 COS-7 细胞提取物

Biochem/physiol Actions

CDH11 基因编码一种介导钙依赖性细胞间黏附的 Ⅱ 类型经典钙粘蛋白。
在肿瘤细胞中观察到CDH2基因的更高表达。现已确知它诱导癌细胞的侵袭性和化学抗性。N-钙粘着蛋白的N-糖基化与肿瘤发生过程有关，特别是与乳腺、肾系统和卵巢中的肿瘤发生过程有关。在肾上腺皮质癌中观察到该基因没有表达。

Disclaimer

除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或人类或动物应用。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

法规信息

常规特殊物品
常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000522447
0000522447
0000508935
0000508935
0000453484

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Priscilla Y Hwang et al.
Cellular and molecular bioengineering, 8(1), 51-62 (2015-04-08)
Juvenile nucleus pulposus (NP) cells of the intervertebral disc (IVD) are large, vacuolated cells that form cell clusters with strong cell-cell interactions. With maturation and aging, NP cells lose their ability to form these cell clusters, with aging-associated changes in
Priscilla Y Hwang et al.
Scientific reports, 6, 28038-28038 (2016-06-14)
Nucleus pulposus (NP) cells of the intervertebral disc are essential for synthesizing extracellular matrix that contributes to disc health and mechanical function. NP cells have a unique morphology and molecular expression pattern derived from their notochordal origin, and reside in
Kristine Boisen Olsen et al.
Cardiovascular diabetology, 12, 19-19 (2013-01-19)
Diabetes increases the risk of cardiovascular complications including arrhythmias, but the underlying mechanisms remain to be established. Decreased conduction velocity (CV), which is an independent risk factor for re-entry arrhythmias, is present in models with streptozotocin (STZ) induced type 1
N-Glycosylation at Asn 402 Stabilizes N-Cadherin and Promotes Cell-Cell Adhesion of Glioma Cells.
Xu Y, et al.
Journal of Cellular Biochemistry, 118(6), 1423-1431 (2017)
Telomerase and N-Cadherin Differential Importance in Adrenocortical Cancers and Adenomas.
Pereira SS, et al.
Journal of Cellular Biochemistry, 118(8), 2064-2071 (2017)
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