C3662

环孢菌素A

Name: 环孢菌素A
Brand: SIGMA

from Tolypocladium inflatum, ≥95% (HPLC), solid, Calcineurin inhibitor

别名:

抗生素S 7481F1, 环孢霉素

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关于此项目

经验公式（希尔记法）:

C₆₂H₁₁₁N₁₁O₁₂

化学文摘社编号:

59865-13-3

分子量:

1202.61

NACRES:

NA.77

PubChem Substance ID:

24278028

UNSPSC Code:

12352200

MDL number:

MFCD00274558

Beilstein/REAXYS Number:

3647785

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产品名称

环孢菌素A, from Tolypocladium inflatum, ≥95% (HPLC), solid

Quality Level

300

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

SMILES string

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

InChI key

PMATZTZNYRCHOR-CGLBZJNRSA-N

biological source

Tolypocladium inflatum

assay

≥95% (HPLC)

form

solid

color

white

solubility

dichloromethane: 10 mg/mL, ethanol: 10 mg/mL, DMSO: 50 mg/mL, chloroform: 6 mg/mL, H₂O: insoluble

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

originator

Novartis

storage temp.

2-8°C

Gene Information

human ... PPIA(5478), PPP3CA(5530), PPP3CB(5532), PPP3CC(5533), PPP3R1(5534), PPP3R2(5535)

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Biochem/physiol Actions

一种具有强大的免疫抑制特性的真菌代谢物。它通过形成抑制钙调神经磷酸酶（蛋白磷酸酶 2B）的环孢菌素A−亲环蛋白复合物来抑制 T 细胞受体的信号转导途径。抑制由白介素1α、脂多糖和TNFα诱导的一氧化氮合成。阻止线粒体释放细胞色素 c。

强效免疫抑制剂；抑制由白介素1α、脂多糖和TNFα诱导的一氧化氮合成；阻止线粒体释放细胞色素 c。

Features and Benefits

该化合物在受体分类和信号转导手册中磷酸蛋白磷酸酶（丝氨酸/苏氨酸）页面中进行了详细介绍。欲浏览其他手册页面，请点击这里。

该化合物是ADME Tox研究推荐产品。点击此处，查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

该化合物是由 Novartis开发。浏览其他由制药公司开发的化合物以及批准药物/候选药物清单，请单击此处。

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H350,H360FD

pcodes

P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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环孢菌素A

from Tolypocladium inflatum, ≥95% (HPLC), solid, Calcineurin inhibitor

选择尺寸

关于此项目

主要文件

属性

产品名称

Quality Level

InChI

SMILES string

InChI key

biological source

assay

form

color

solubility

antibiotic activity spectrum

mode of action

originator

storage temp.

Gene Information

相关类别

说明

Biochem/physiol Actions

Features and Benefits

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

wgk

ppe

法规信息

文件

分析证书(COA)

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