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文件

安全信息

C3662

Sigma-Aldrich

环孢菌素A

from Tolypocladium inflatum, ≥95% (HPLC), solid, Calcineurin inhibitor

别名:

抗生素S 7481F1, 环孢霉素

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About This Item

经验公式（希尔记法）:
C62H111N11O12
CAS号:
59865-13-3
分子量:
1202.61
Beilstein:
3647785
MDL编号:
MFCD00274558
UNSPSC代码:
12352200
PubChem化学物质编号:
24278028
NACRES:
NA.77

product name

环孢菌素A, from Tolypocladium inflatum, ≥95% (HPLC), solid

生物来源

Tolypocladium inflatum

质量水平

300

检测方案

≥95% (HPLC)

形式

solid

颜色

white

溶解性

dichloromethane: 10 mg/mL
ethanol: 10 mg/mL
DMSO: 50 mg/mL
chloroform: 6 mg/mL
H2O: insoluble

抗生素抗菌谱

fungi

作用机制

enzyme | inhibits

创始人

Novartis

储存温度

2-8°C

SMILES字符串

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChI key

PMATZTZNYRCHOR-CGLBZJNRSA-N

基因信息

human ... PPIA(5478) , PPP3CA(5530) , PPP3CB(5532) , PPP3CC(5533) , PPP3R1(5534) , PPP3R2(5535)

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生化/生理作用

一种具有强大的免疫抑制特性的真菌代谢物。它通过形成抑制钙调神经磷酸酶（蛋白磷酸酶 2B）的环孢菌素A−亲环蛋白复合物来抑制 T 细胞受体的信号转导途径。抑制由白介素1α、脂多糖和TNFα诱导的一氧化氮合成。阻止线粒体释放细胞色素 c。

特点和优势

该化合物在受体分类和信号转导手册中 磷酸蛋白磷酸酶（丝氨酸/苏氨酸） 页面中进行了详细介绍。欲浏览其他手册页面，请 点击这里。
该化合物是ADME Tox研究推荐产品。点击此处 ，查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
该化合物是由 Novartis开发。浏览其他由制药公司开发的化合物以及批准药物/候选药物清单， 请单击此处。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险声明

H302,H350,H360FD

危险分类

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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