推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 27 kDa
种属反应性
mouse, human, rat
技术
immunohistochemistry (frozen sections): 1:400 using frozen rat liver sections
western blot: 1:400 using a rat liver membrane preparation
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GJB1(2705)
mouse ... Gjb1(14618)
rat ... Gjb1(29584)
一般描述
Connexins (Cx) are a multi-gene family of highly related proteins with molecular weights ranging from 26 to 70 kDa. The structure of connexin molecules includes a cytoplasmic N-terminal region, four transmembrane domains, two extracellular loops, and a C-terminal cytoplasmic tail of varying length. The 27kD connexin protein (connexin 32, Cx32) is expressed in several tissues.
免疫原
synthetic human connexin-32 peptide (amino acids 106-124).
应用
Anti-Connexin 32 (265-279) antibody produced in rabbit is suitable for immunohistochemistry (frozen sections) at a dilution of 1:400 using frozen rat liver tissue. It is also suitable for western blot at a dilution of 1:400 using a rat liver membrane preparation.
Anti-Connexin-32 (106-124) antibody produced in rabbit has been used in:
- western blotting
- immunofluorescence
- immunohistology
生化/生理作用
Cx32 mutations is associated with X-linked Charcot-Marie-Tooth (CMTX) disease, which leads to myelin disruption and axonal degeneration.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin with 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Diego López et al.
Experimental physiology, 94(10), 1088-1097 (2009-07-21)
Previous studies demonstrated that intercellular communication through endothelial, smooth muscle or myoendothelial connexin channels contributes to the control of vascular tone. At least four connexin types are present in the arterial wall. The aim of the present work was to
Transient, recurrent, white matter lesions in X-linked Charcot-Marie-Tooth disease with novel connexin 32 mutation
Hanemann CO, et al.
Archives of Neurology, 60(4), 605-609 (2003)
Effects of substitution of Cx43 by Cx32 on myocardial energy metabolism, tolerance to ischaemia and preconditioning protection
Rodriguez-Sinovas A, et al.
The Journal of Physiology, 588(7), 1139-1151 (2010)
The expression of mesenchymal, neural and haematopoietic stem cell markers in adult hepatocytes proliferating in vitro
Koenig S, et al.
Journal of Hepatology, 44(6), 1115-1124 (2006)
Silvia Ravera et al.
Molecular neurobiology, 53(4), 2468-2479 (2015-06-03)
Recently, we have demonstrated that myelin conducts an extramitochondrial oxidative phosphorylation, hypothesizing a novel supportive role for myelin in favor of the axon. We have also hypothesized that the ATP produced in myelin could be transferred thought gap junctions. In
商品
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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