生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
6D4, monoclonal
包含
15 mM sodium azide as preservative
种属反应性
chicken, Dictyostelium discoideum, bovine, rat
技术
western blot: 1:2,000 using a bovine brain calmodulin preparation
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
rat ... Calm1(24242)
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一般描述
Calmodulin belongs to a family of structurally homologous Ca2+-binding proteins. CALM1 gene is located on human chromosome 14q32.11.
Calmodulin is a highly conserved 17kDa calcium binding protein found in all eukaryotic cells. It is a multifunctional molecule. Monoclonal anti-Calmodulin (mouse IgG1 isotype) is derived from the 6D4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with calmodulin, purified from Dictyostelium discoideum and conjugated to KLH.
特异性
The antibody recognizes native and SDS-denatured calmodulin.
These antibodies are directed against different epitopes within the calmodulin molecule.
免疫原
preparation of purified calmodulin from Dictyostelium discoideum conjugated to KLH.
应用
Monoclonal Anti-Calmodulin antibody produced in mouse has been used in:
- enzyme-linked immunosorbent assay (ELISA)
- immunoblot
- dot blot
- immunocytochemistry
- immunoprecipitation
- immunofluorescence
生化/生理作用
Calmodulin is a ubiquitous molecule which can bind up to 4 calcium ions, regulating and mediating a wide variety of biochemical processes.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The role of calmodulin and related proteins in plant cell function: an ever-thickening plot
Bergey DR, et al.
Springer Science Reviews, 2(1-2), 145-159 (2014)
Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared with adult ovine carotid arteries
Injeti ER, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 295(6), H2289-H2298 (2008)
The role of calmodulin and related proteins in plant cell function: an ever-thickening plot
Bergey DR, et al.
Springer Science Reviews, 2(1-2), 145-159 (2014)
Association between the polymorphisms of CALM1 gene and osteoarthritis risk: a meta-analysis based on observational studies
Yang H, et al.
Bioscience Reports, 38(5), BSR20181128-BSR20181128 (2018)
H C Lee et al.
The Journal of biological chemistry, 270(16), 9060-9066 (1995-04-21)
Cyclic ADP-ribose (cADPR) is emerging as an endogenous regulator of Ca2+-induced Ca2+ release (CICR), and we have recently demonstrated that its action is mediated by calmodulin (CaM) (Lee, H. C., Aarhus, R., Graeff, R., Gurnack, M. E., and Walseth, T.
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