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安全信息

C3394

Sigma-Aldrich

虫草素

from Cordyceps militaris, ≥98% (HPLC), powder, adenosine analogue

别名:

3′-脱氧腺苷

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About This Item

经验公式（希尔记法）:
C10H13N5O3
CAS号:
73-03-0
分子量:
251.24
Beilstein:
35194
EC 号:
200-791-4
MDL编号:
MFCD00037998
UNSPSC代码:
12352200
PubChem化学物质编号:
24892611
NACRES:
NA.77

product name

虫草素, from Cordyceps militaris

生物来源

Cordyceps militaris

质量水平

200

形式

powder

抗生素抗菌谱

fungi

作用机制

DNA synthesis | interferes
enzyme | inhibits

储存温度

−20°C

SMILES字符串

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)C[C@H]3O

InChI

1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1

InChI key

OFEZSBMBBKLLBJ-BAJZRUMYSA-N

基因信息

rat ... Adora1(29290)

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一般描述

化学结构：核苷

生化/生理作用

虫草素是一种腺苷类似物，易于转化为5′-三磷酸虫草素；可用于RNA的3′-端标记。

特点和优势

该化合物是受体分类及信号转导手册上腺苷酸环化酶页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
该化合物是环核苷酸和基因调控研究的特色产品。发现更多环核苷酸和基因调控特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301 + H311 + H331

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

分析证书(COA)

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E N Kodama et al.
Biochemical pharmacology, 59(3), 273-281 (1999-12-28)
The nucleoside analogue cordycepin (3'-deoxyadenosine, 3'-dA) is substantially more cytotoxic to terminal deoxynucleotidyl transferase positive (TdT+) leukemic cells than to TdT leukemic cells in vitro in the presence of an adenosine deaminase inhibitor, deoxycoformycin (dCF), and has been considered as
Guifen Wu et al.
Cell reports, 30(7), 2387-2401 (2020-02-23)
Degradation of transcripts in human nuclei is primarily facilitated by the RNA exosome. To obtain substrate specificity, the exosome is aided by adaptors; in the nucleoplasm, those adaptors are the nuclear exosome-targeting (NEXT) complex and the poly(A) (pA) exosome-targeting (PAXT) connection.
Yukako Chiba et al.
Plant & cell physiology, 54(2), 180-194 (2012-12-12)
Control of mRNA half-life is a powerful strategy to adjust individual mRNA levels to various stress conditions, because the mRNA degradation rate controls not only the steady-state mRNA level but also the transition speed of mRNA levels. Here, we analyzed
Ying-Yi Chen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(8-9), 768-778 (2012-04-03)
Cancer metastasis is a primary cause of cancer death. Antrodia cinnamomea (A. cinnamomea), a medicinal mushroom in Taiwan, has been shown antioxidant and anticancer activities. In this study, we first observed that ethanol extract of fruiting bodies of A. cinnamomea
Suman K Vodnala et al.
Journal of medicinal chemistry, 56(24), 9861-9873 (2013-11-29)
Novel methods for treatment of African trypanosomiasis, caused by infection with Trypanosoma brucei are needed. Cordycepin (3'-deoxyadenosine, 1a) is a powerful trypanocidal compound in vitro but is ineffective in vivo because of rapid metabolic degradation by adenosine deaminase (ADA). We
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