形式
powder
质量水平
药品控制
USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)
技术
HPLC: suitable
gas chromatography (GC): suitable
溶解性
H2O: soluble
ethanol: soluble
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
储存温度
2-8°C
SMILES字符串
Cl.C[C@H](N)C(=O)c1ccccc1
InChI
1S/C9H11NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7H,10H2,1H3;1H/t7-;/m0./s1
InChI key
HPZCAKYHISJOIK-FJXQXJEOSA-N
一般描述
Cathinone is a monoamine alkaloid of Khat shrub. It is a β-keto derivative of amphetamine. Cathinone is structurally similar to dopamine and amphetamine. A synthetic cathinone is categorized as a new psychoactive substance.
生化/生理作用
Cathinone is the major central nervous system stimulant. Like amphetamine, it is a potent releaser of norepinephrine and dopamine from their intracellular stores. Cathinone derivates are known to have prolonged effects on nervous and blood vascular systems. The mode of action of its derivative is by inhibiting the reuptake of neurotransmitters and stimulating cathinone-sensitive receptors.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
监管及禁止进口产品
D J Calcagnetti et al.
Progress in neuro-psychopharmacology & biological psychiatry, 17(4), 637-649 (1993-07-01)
1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats conditioned with 16 or 32 micrograms
A E Fleckenstein et al.
European journal of pharmacology, 382(1), 45-49 (1999-11-11)
High-dose administrations of amphetamine, methamphetamine, cathinone, methcathinone or methylenedioxymethamphetamine rapidly decrease dopamine and serotonin transporter function in vivo, as assessed in striatal synaptosomes obtained from drug-treated rats. In contrast, high-dose injections of fenfluramine, cocaine or methylphenidate had little or no
Issues of false negative results in toxicology: difficult in detecting certain drugs and issues with detection of synthetic cathinone (bath salts), synthetic cannabinoids (spice), and other new psychoactive substances
Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, 257-270 (2019)
E A Pehek et al.
Neuropharmacology, 29(12), 1171-1176 (1990-12-01)
The effects of (-)cathinone, the primary psychoactive alkaloid of the Khat plant, were compared to those of (+)amphetamine in the anterior caudate-putamen and the nucleus accumbens. In vivo microdialysis was used to measure extracellular levels of dopamine and metabolites in
Marcin Rojkiewicz et al.
Forensic toxicology, 36(1), 141-150 (2018-01-26)
In this study, we performed identification and physicochemical characterization of two cathinone derivatives, 4-FPD and 4-MEAP, found in market-available materials. The compounds were characterized by electrospray ionization ion trap mass spectrometry (MS) in MS2 and MS3 modes, gas chromatography-MS, infrared
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