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About This Item
经验公式（希尔记法）:
C21H36N7O16P3S · xNa+ · yH2O
CAS号:
分子量:
767.53 (anhydrous free acid basis)
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
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描述
cofactor for acyl transfer
质量水平
方案
≥85% (spectrophotometric assay)
表单
powder
溶解性
H2O: soluble 50 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
InChI key
SYTRWOCXZXQBPW-CLVRNSBASA-M
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一般描述
辅酶A(CoA)是生命系统中必不可少的辅因子，由泛酸（维生素B5）合成。线粒体和过氧化物酶体中的CoA水平分别对应于2-5 mM和0.7 mM。胞质CoA的范围在0.05 mM至0.14 mM之间
应用
辅酶A适用于：
- 猪脂肪组织中甘油酯的生物合成
- 使用纳米粒子电化学生物传感器对人血液样本中α-甲基酰基-CoA消旋酶（AMACR）水平进行检测
- 氯霉素乙酰转移酶（CAT）的测定
- 棕榈酰辅酶A的合成（用于调节膜融合蛋白的棕榈酰化和活化）
生化/生理作用
辅酶 A（CoA、CoASH、HSCoA）是促进酶促酰基转移反应，并支持脂肪酸合成和氧化的辅酶。CoA可参与多种酶反应机制。在CoASH存在下，有机羧酸可形成酰基辅酶A硫酯，其可促进酶的识别。由异生素羧酸形成的酰基辅酶A会增加化合物的毒性，这可导致细胞代谢功能障碍。它参与Kreb′s循环中丙酮酸的氧化。CoA是代谢活动所需的成分。细菌CoA途径是抗菌药开发的靶标。这一成分可介导酰基转移和羰基活化。CoA及其硫酯水平对于细胞动态平衡至关重要。CoA还参与调节血小板聚集和血管收缩。在酶促乙酰转移反应中，它起着重要的辅助因子作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
D C Rule et al.
Journal of animal science, 67(2), 364-373 (1989-02-01)
To compare genetic differences in glycerolipid biosynthesis, rates were determined in s.c. adipose tissue of lean and obese pigs at 28, 60 and 110 d of age. To compare depot-specific differences, glycerolipid biosynthetic rates were determined in outer s.c., middle
Christoph Matti et al.
Journal of leukocyte biology, 107(6), 1137-1154 (2020-06-14)
The chemokine CCL20 is broadly produced by endothelial cells in the liver, the lung, in lymph nodes and mucosal lymphoid tissues, and recruits CCR6 expressing leukocytes, particularly dendritic cells, mature B cells, and subpopulations of T cells. How CCL20 is
E P Brass
Chemico-biological interactions, 90(3), 203-214 (1994-03-01)
Coenzyme A (CoASH) has a clearly defined role as a cofactor for a number of oxidative and biosynthetic reactions in intermediary metabolism. Formation of acyl-CoA thioesters from organic carboxylic acids activates the acid for further biotransformation reactions and facilitates enzyme
Po-Yuan Lin et al.
Biosensors, 2(4), 377-387 (2012-01-01)
Although still commonly used in clinical practice to screen and diagnose prostate cancer, there are numerous weaknesses of prostate-specific antigen (PSA) testing, including lack of specificity and the inability to distinguish between aggressive and indolent cancers. A promising prostate cancer
Christoph Matti et al.
Frontiers in immunology, 11, 720-720 (2020-05-12)
Chemokines are essential for guiding cell migration. Atypical chemokine receptors (ACKRs) contribute to the cell migration process by binding, internalizing and degrading local chemokines, which enables the formation of confined gradients. ACKRs are heptahelical membrane spanning molecules structurally related to
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