C3144
辅酶 A 钠盐 水合物
cofactor for acyl transfer
别名:
CoA Na2
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关于此项目
经验公式（希尔记法）:
C21H36N7O16P3S · xNa+ · yH2O
化学文摘社编号:
分子量:
767.53 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
EC Number:
259-747-8
NACRES:
NA.51
产品名称
辅酶 A 钠盐 水合物, cofactor for acyl transfer
InChI key
SYTRWOCXZXQBPW-CLVRNSBASA-M
SMILES string
[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
description
cofactor for acyl transfer
assay
≥85% (spectrophotometric assay)
form
powder
solubility
H2O: soluble 50 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
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Application
辅酶A适用于：
- 猪脂肪组织中甘油酯的生物合成
- 使用纳米粒子电化学生物传感器对人血液样本中α-甲基酰基-CoA消旋酶（AMACR）水平进行检测
- 氯霉素乙酰转移酶（CAT）的测定
- 棕榈酰辅酶A的合成（用于调节膜融合蛋白的棕榈酰化和活化）
Biochem/physiol Actions
辅酶 A（CoA、CoASH、HSCoA）是促进酶促酰基转移反应，并支持脂肪酸合成和氧化的辅酶。CoA可参与多种酶反应机制。在CoASH存在下，有机羧酸可形成酰基辅酶A硫酯，其可促进酶的识别。由异生素羧酸形成的酰基辅酶A会增加化合物的毒性，这可导致细胞代谢功能障碍。它参与Kreb′s循环中丙酮酸的氧化。CoA是代谢活动所需的成分。细菌CoA途径是抗菌药开发的靶标。这一成分可介导酰基转移和羰基活化。CoA及其硫酯水平对于细胞动态平衡至关重要。CoA还参与调节血小板聚集和血管收缩。在酶促乙酰转移反应中，它起着重要的辅助因子作用。
General description
辅酶A(CoA)是生命系统中必不可少的辅因子，由泛酸（维生素B5）合成。线粒体和过氧化物酶体中的CoA水平分别对应于2-5 mM和0.7 mM。胞质CoA的范围在0.05 mM至0.14 mM之间
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
D C Rule et al.
Journal of animal science, 67(2), 364-373 (1989-02-01)
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Biosynthesis of pantothenic acid and coenzyme A
LEONARDI R and JACKOWSKI S
Ecosal plus, 2(2) (2007)
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