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Merck
CN
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安全信息

C3130

Sigma-Aldrich

Cortisone 21-acetate

≥99%

别名:

17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate

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About This Item

经验公式（希尔记法）:
C23H30O6
CAS号:
50-04-4
分子量:
402.48
Beilstein:
2067543
EC 号:
200-006-5
MDL编号:
MFCD00003609
UNSPSC代码:
51111800
PubChem化学物质编号:
24278306
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

200

无菌性

non-sterile

方案

≥99%

表单

powder

mp

237-240 °C (lit.)

溶解性

chloroform: 50 mg/mL, clear, colorless to faintly yellow

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1

InChI key

ITRJWOMZKQRYTA-RFZYENFJSA-N

基因信息

human ... FNTA(2339) , NR3C1(2908)

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一般描述

Cortisone 21-acetate is a prodrug, which has glucocorticoid and mineralocorticoid properties. It is used as a therapeutic option for glucocorticoid replacement.

应用

Cortisone 21-acetate has been used to study its effects in metastasis and phagocytic activity.

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361d

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
0000276452
0000276450
0000276451
0000223207
0000255697

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Replacement therapy in Addison?s disease
Lovaas K and Husebye ES
Expert Opinion on Pharmacotherapy (2003)
D M Dixon et al.
Infection and immunity, 57(5), 1452-1456 (1989-05-01)
We report on a model of primary pulmonary aspergillosis occurring after intranasal instillation of concentrated suspensions of conidia of Aspergillus fumigatus in immunocompromised mice. Unconcentrated suspensions of inoculum contained ca. 2 x 10(7) conidia per ml (1x). These suspensions were
Lin Lin et al.
The Journal of infectious diseases, 205(2), 337-347 (2011-11-30)
Activated transfected killer (ATAK) cells are immortal phagocytes transfected with a luminescence reporter that effectively treat lethal infections in neutropenic mice. Their in vivo trafficking, lifespan, and immunogenicity are unknown. Mice were made neutropenic; infected or not with Staphylococcus aureus
Immunological mechanisms in metastatic spread and the antimetastatic effects of C. parvum
Jones PD and Castro JE
British Journal of Cancer, 35(5), 519-519 (1977)
Ana Gil-Bona et al.
Journal of proteomics, 127(Pt B), 340-351 (2015-06-19)
The ability to switch from yeast to hyphal growth is essential for virulence in Candida albicans. The cell surface is the initial point of contact between the fungus and the host. In this work, a free-gel proteomic strategy based on
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