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Merck
CN
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文件

安全信息

C3130

Sigma-Aldrich

Cortisone 21-acetate

≥99%

别名:

17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate

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About This Item

经验公式（希尔记法）:
C23H30O6
CAS号:
50-04-4
分子量:
402.48
Beilstein:
2067543
EC 号:
200-006-5
MDL编号:
MFCD00003609
UNSPSC代码:
51111800
PubChem化学物质编号:
24278306
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

200

无菌性

non-sterile

检测方案

≥99%

形式

powder

mp

237-240 °C (lit.)

溶解性

chloroform: 50 mg/mL, clear, colorless to faintly yellow

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1

InChI key

ITRJWOMZKQRYTA-RFZYENFJSA-N

基因信息

human ... FNTA(2339) , NR3C1(2908)

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相关类别

一般描述

Cortisone 21-acetate is a prodrug, which has glucocorticoid and mineralocorticoid properties. It is used as a therapeutic option for glucocorticoid replacement.

应用

Cortisone 21-acetate has been used to study its effects in metastasis and phagocytic activity.

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361d

危险分类

Repr. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Ana Gil-Bona et al.
Journal of proteomics, 127(Pt B), 340-351 (2015-06-19)
The ability to switch from yeast to hyphal growth is essential for virulence in Candida albicans. The cell surface is the initial point of contact between the fungus and the host. In this work, a free-gel proteomic strategy based on
Immunological mechanisms in metastatic spread and the antimetastatic effects of C. parvum
Jones PD and Castro JE
British Journal of Cancer, 35(5), 519-519 (1977)
Lin Lin et al.
The Journal of infectious diseases, 205(2), 337-347 (2011-11-30)
Activated transfected killer (ATAK) cells are immortal phagocytes transfected with a luminescence reporter that effectively treat lethal infections in neutropenic mice. Their in vivo trafficking, lifespan, and immunogenicity are unknown. Mice were made neutropenic; infected or not with Staphylococcus aureus
Replacement therapy in Addison?s disease
Lovaas K and Husebye ES
Expert Opinion on Pharmacotherapy (2003)
Wiebke Arlt et al.
Clinical endocrinology, 64(4), 384-389 (2006-04-06)
Evaluation of glucocorticoid replacement quality in adrenal insufficiency (AI) relies primarily on clinical judgement and thus largely depends on the physician's expertise. It is a matter of debate whether cortisol day curves are of value in assessing glucocorticoid replacement quality.
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